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Autoimmune Diseases
Volume 2011 (2011), Article ID 629538, 3 pages
http://dx.doi.org/10.4061/2011/629538
Review Article

Vitamin D and Multiple Sclerosis: Correlation, Causality, and Controversy

1Division of Clinical and Experimental Immunology, Department of Internal Medicine and School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, P.O. Box 616, 6200 MD Maastricht, The Netherlands
2Academic MS Center Limburg, Orbis Medical Center, P.O. Box 5500, 6130 MB Sittard, The Netherlands

Received 13 September 2010; Accepted 14 September 2010

Academic Editor: Sreeram Ramagopalan

Copyright © 2011 Joost Smolders. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. D. Acheson, C. A. Bachrach, and F. M. Wright, “Some comments on the relationship of the distribution of multiple sclerosis to latitude, solar radiation, and other variables,” Acta Psychiatrica Scandinavica, vol. 35, no. 147, pp. 132–147, 1960. View at Google Scholar
  2. J. Smolders, J. Damoiseaux, P. Menheere, and R. Hupperts, “Vitamin D as an immune modulator in multiple sclerosis, a review,” Journal of Neuroimmunology, vol. 194, no. 1-2, pp. 7–17, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Ascherio, K. L. Munger, and K. C. Simon, “Vitamin D and multiple sclerosis,” Lancet Neurology, vol. 9, no. 6, pp. 599–612, 2010. View at Publisher · View at Google Scholar
  4. P. Goldberg, M. C. Fleming, and E. H. Picard, “Multiple sclerosis: decreased relapse rate through dietary supplementation with calcium, magnesium and vitamin D,” Medical Hypotheses, vol. 21, no. 2, pp. 193–200, 1986. View at Google Scholar · View at Scopus
  5. R. Wüthrich and H. P. Rieder, “The seasonal incidence of multiple sclerosis in Switzerland,” European Neurology, vol. 3, no. 5, pp. 257–264, 1970. View at Google Scholar · View at Scopus
  6. D. P. Auer, E. M. Schumann, T. Kümpfel, C. Gössl, and C. Trenkwalder, “Seasonal fluctuations of gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis,” Annals of Neurology, vol. 47, no. 2, pp. 276–277, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. B. W. Hollis, “Assessment of vitamin D nutritional and hormonal status: what to measure and how to do it,” Calcified Tissue International, vol. 58, no. 1, pp. 4–5, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. J. F. Kurtzke, “Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS),” Neurology, vol. 33, no. 11, pp. 1444–1452, 1983. View at Google Scholar · View at Scopus
  9. J. Smolders, P. Menheere, A. Kessels, J. Damoiseaux, and R. Hupperts, “Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis,” Multiple Sclerosis, vol. 14, no. 9, pp. 1220–1224, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. I. A. F. van der Mei, A.-L. Ponsonby, T. Dwyer et al., “Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia,” Journal of Neurology, vol. 254, no. 5, pp. 581–590, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. J. M. Burton, S. Kimball, R. Vieth et al., “A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis,” Neurology, vol. 74, no. 23, pp. 1852–1859, 2010. View at Publisher · View at Google Scholar
  12. J. Correale, M. C. Ysrraelit, and M. I. Gaitán, “Immunomodulatory effects of Vitamin D in multiple sclerosis,” Brain, vol. 132, no. 5, pp. 1146–1160, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Soilu-Hänninen, L. Airas, I. Mononen, A. Heikkilä, M. Viljanen, and A. Hänninen, “25-hydroxyvitamin D levels in serum at the onset of multiple sclerosis,” Multiple Sclerosis, vol. 11, no. 3, pp. 266–271, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Soilu-Hänninen, M. Laaksonen, I. Laitinen, J.-P. Erälinna, E.-M. Lilius, and I. Mononen, “A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 79, no. 2, pp. 152–157, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Simpson Jr., B. Taylor, L. Blizzard et al., “Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis,” Annals of Neurology, vol. 68, no. 2, pp. 193–203, 2010. View at Publisher · View at Google Scholar
  16. E. M. Mowry, L. B. Krupp, M. Milazzo et al., “Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis,” Annals of Neurology, vol. 67, no. 5, pp. 618–624, 2010. View at Publisher · View at Google Scholar
  17. S. M. Kimball, M. R. Ursell, P. O'Connor, and R. Vieth, “Safety of vitamin D3 in adults with multiple sclerosis,” American Journal of Clinical Nutrition, vol. 86, no. 3, pp. 645–651, 2007. View at Google Scholar · View at Scopus
  18. B. R. Becklund, K. S. Severson, S. V. Vang, and H. F. DeLuca, “UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 14, pp. 6418–6423, 2010. View at Publisher · View at Google Scholar
  19. J. Smolders, M. Thewissen, E. Peelen et al., “Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis,” PLoS ONE, vol. 4, no. 8, article e6635, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Holmøy, S. M. Moen, T. A. Gundersen et al., “25-hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis,” Multiple Sclerosis, vol. 15, no. 11, pp. 1280–1285, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. S.-M. Orton, A. P. Morris, B. M. Herrera et al., “Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis,” American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 441–447, 2008. View at Google Scholar · View at Scopus
  22. S. V. Ramagopalan, N. J. Maugeri, L. Handunnetthi et al., “Expression of the multiple sclerosis-associated MHC class II allele HLA-DRB1*1501 is regulated by vitamin D,” PLoS Genetics, vol. 5, no. 2, Article ID e1000369, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Knippenberg, Y. Bol, J. Damoiseaux, R. Hupperts, and J. Smolders, “Vitamin D status in MS patients is negatively correlated with depression, but not with fatigue,” Acta Neurologica Scandinavica. In press. View at Publisher · View at Google Scholar
  24. D. J. Llewellyn, I. A. Lang, K. M. Langa et al., “Vitamin D and risk of cognitive decline in elderly persons,” Archives of Internal Medicine, vol. 170, no. 13, pp. 1135–1141, 2010. View at Publisher · View at Google Scholar