Heterogeneity in Multiple Sclerosis: Scratching the Surface of a Complex Disease

Table 2

Reported HLA class II and class I associations across the world.

	Population	Approximate OR	Reference
HLA-DRB1 alleles
	Canada		[26, 27]
*01	Sweden	0.6	[32]
	UK, US		[31]
*03	Canada	1.7	[26, 27]
	Sweden,		[24]
	UK, US, Italy, Spain		[25]
	Sardinia		[29]
*04	Sardinia	2.2	[29]
*07	Italy	0.6	[22]
*08	Canada	1.7	[26, 27]
	UK, US, Italy, Spain	(15/8 genotype)	[25]
*09	Japan	0.4	[28]
*10	Canada	0.7	[26, 27]
*11	Canada	0.7	[26, 27]
*13	Sardinia	2	[29]
	Israel		[23]
*14	Canada,	0.3	[26, 27]
	UK, US, Italy, Spain		[25]
*15	Near-universal	3
HLA-class I alleles
A*02	Sweden	0.6	[33]
	Italy		[31]
B*44	UK, US	0.4	[34]
Cw*05	UK, US	<1	[32]