Heterogeneity in Multiple Sclerosis: Scratching the Surface of a Complex Disease

Table 3

List of established non-MHC MS-associated genes.

Gene	Proposed function	CH	OR	UCSC Microarray expression data	References
IL7Ra	Cytokine receptor	5	1.18	CD4+ T cells ++++, CD8+ T cells ++++,	[38–42, 44]
Interleukin 7 receptor				CD56+ NK +++, BCDA4+DCs ++,
				CD14+ Monocytes+
IL2Ra	Cytokine receptor	10	1.19	CD4+ T cells ++, CD8+ T cells +,	[37, 38, 40, 42]
Interleukin 2 receptor				CD56+ NK +
CLEC16A	Sugar binding C type lectin	16	1.18	CD19+ B cells +, CD56+ NK +,	[45, 48, 49, 53]
C lectin domain A				BCDA4+DCs +
CD58	Ligand of CD2/T cell activation	1	1.30	CD56+ NK ++++, CD14+ Monocytes++++,	[37, 38, 43, 45, 49]
				CD8+ T cells +++, CD19+ B cells++,
				CD4+ T cells ++, BCDA4+DCs ++
CD6	Cell signaling/T cell activation	11	1.18	CD4+ T cells ++++, CD8+ T cells ++++,	[54]
				CD56+ NK +++, BCDA4+DCs +
IRF8	Interferon regulatory factor	16	0.80	CD19+ B cells ++++, BCDA4+DCs ++++,	[54]
Interferon regulatory				CD56+ NK ++, CD14+ Monocytes ++,
factor 8				CD4+ T cells +, CD8+ T cells +
CD226	Cell-cell adhesion	18	1.11	CD56+ NK ++	[50, 53]
TNFRSF1A	Tumor necrosis factor receptor	12	1.20	CD14+ Monocytes +++, CD56+ NK ++,	[54]
Tumor necrosis factor				BCDA4+DCs +, CD4+ T cells +,
receptor 1				CD8+ T cells +
EVI5	Cell cycle regulation	1	1.1	BCDA4+DCs +, CD14+ Monocytes +,	[37, 45, 51]
Ecotropic viral				CD19+ B cells+
integration site 5
CD40	Tumor Necrosis Factor receptor	20	1.20	CD56+ NK +, CD14+ Monocytes +,	[45]
	Super family member 5			BCDA4+DCs +
TYK2	Cell signaling	19	1.32	CD56+ NK +++, CD14+ Monocytes +++,	[44, 45]
Tyrosine kinase 2				BCDA4+DCs +++, CD8+ T cells ++,
				CD19+ B cells ++, CD4+ T cells ++
KIF1B	Axonal transport	1	1.34	Whole brain ++++	[47]
Kinesin family member
1B

⁺Increasing number of crosses correspond to increasing expression levels.