Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet’s Disease

Figure 4

HSP60 regulates Th1 cell differentiation through multiple pathways, a hypothesis. The interactions between TCR- and HSP-derived peptides on MHC [22] and between IL-12 and its receptor [8–10] may induce aberrant T-cell differentiation in patients with BD (Figure 4). The interaction between MIP1β and C-C-type chemokine receptor (CCR)5 was suggested to induce migration of the pathogenic T cells [8]. TLR2/6 heterodimer is involved in IL-6 production [51] and thus we need to study the expression of the heterodimer in patients with BD.