Table of Contents Author Guidelines Submit a Manuscript
Autoimmune Diseases
Volume 2012, Article ID 197648, 6 pages
http://dx.doi.org/10.1155/2012/197648
Research Article

The Role of M. leprae Hsp65 Protein and Peptides in the Pathogenesis of Uveitis

1Department of Ophthalmology, São Paulo Hospital, Federal University of São Paulo, R. Botucatu 820, 04023-062 São Paulo, SP, Brazil
2Hospital Israelita Albert Einstein, Avenue Albert Einstein 627-701, 2 Subsolo Bloco A, 05651-901 São Paulo, SP, Brazil
3Department of Immunology, University of São Paulo, R. Prof. Dr. Lineu Prestes 1730, 05508-900 São Paulo, SP, Brazil
4Center for Applied Toxinology (CAT/CEPID), Butantan Institute, Avenue Vital Brazil 1500, 05503-900 São Paulo, SP, Brazil
5Immunochemistry Laboratory, Butantan Institute, Avenue Vital Brazil 1500, 05503-900 São Paulo, SP, Brazil

Received 12 June 2012; Accepted 26 July 2012

Academic Editor: Kamal D. Moudgil

Copyright © 2012 Alessandra Gonçalves Commodaro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. R. Caspi, F. G. Roberge, C. C. Chan et al., “A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens,” Journal of Immunology, vol. 140, no. 5, pp. 1490–1495, 1988. View at Google Scholar · View at Scopus
  2. L. V. Rizzo, P. Silver, B. Wiggert et al., “Establishment and characterization of a murine CD4+ T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice,” Journal of Immunology, vol. 156, no. 4, pp. 1654–1660, 1996. View at Google Scholar · View at Scopus
  3. J. E. R. Thole, P. Hindersson, J. De Bruyn et al., “Antigenic relatedness of a strongly immunogenic 65 kDa mycobacterial protein antigen with a similarly sized ubiquitous bacterial common antigen,” Microbial Pathogenesis, vol. 4, no. 1, pp. 71–83, 1988. View at Google Scholar · View at Scopus
  4. A. K. Dudani and R. S. Gupta, “Immunological characterization of a human homolog of the 65-kilodalton mycobacterial antigen,” Infection and Immunity, vol. 57, no. 9, pp. 2786–2793, 1989. View at Google Scholar · View at Scopus
  5. Q. Xiao, K. Mandal, G. Schett et al., “Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study,” Stroke, vol. 36, no. 12, pp. 2571–2576, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Van Eden, J. E. R. Thole, R. Van der Zee et al., “Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis,” Gynecologic Oncology, vol. 29, no. 1, pp. 171–173, 1988. View at Google Scholar · View at Scopus
  7. I. R. Cohen, “Autoimmunity to chaperonins in the pathogenesis of arthritis and diabetes,” Annual Review of Immunology, vol. 9, pp. 567–589, 1991. View at Google Scholar · View at Scopus
  8. E. B. Marengo, L. V. de Moraes, M. Faria et al., “Administration of M. leprae Hsp65 interferes with the murine lupus progression,” PLoS ONE, vol. 3, no. 8, Article ID e3025, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Direskeneli, A. Hasan, T. Shinnick et al., “Recognition of B-cell epitopes of the 65 kDa HSP in Behçet's Disease,” Scandinavian Journal of Immunology, vol. 43, no. 4, pp. 464–471, 1996. View at Google Scholar · View at Scopus
  10. M. Huhtinen, M. Puolakkainen, K. Laasila, M. Sarvas, A. Karma, and M. Leirisalo-Repo, “Chlamydial antibodies in patients with previous acute anterior uveitis,” Investigative Ophthalmology and Visual Science, vol. 42, no. 8, pp. 1816–1819, 2001. View at Google Scholar · View at Scopus
  11. R. Weltgasser, M. Lechleitner, T. Koch et al., “Antibodies to heat-shock protein 65 and neopterin levels in patients with type 1 diabetes mellitus,” Experimental and Clinical Endocrinology and Diabetes, vol. 111, no. 3, pp. 127–131, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. Q. Xu, J. Willeit, M. Marosi et al., “Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis,” Lancet, vol. 341, no. 8840, pp. 255–259, 1993. View at Publisher · View at Google Scholar · View at Scopus
  13. J. George, D. Harats, B. Gilburd et al., “Immunolocalization of β2-glycoprotein I (apolipoprotein H) to human atherosclerotic plaques: potential implications for lesion progression,” Circulation, vol. 99, no. 17, pp. 2227–2230, 1999. View at Google Scholar · View at Scopus
  14. Y. L. Gao, C. F. Brosnan, and C. S. Raine, “Experimental autoimmune encephalomyelitis: qualitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system,” Journal of Immunology, vol. 154, no. 7, pp. 3548–3556, 1995. View at Google Scholar · View at Scopus
  15. S. M. Anderton, R. Van der Zee, A. Noordzij, and W. Van Eden, “Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols,” Journal of Immunology, vol. 152, no. 7, pp. 3656–3664, 1994. View at Google Scholar · View at Scopus
  16. E. B. Marengo, A. G. Commodaro, J. P. S. Peron et al., “Administration of Mycobacterium leprae rHsp65 aggravates experimental autoimmune uveitis in mice,” PLoS ONE, vol. 4, no. 11, Article ID e7912, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. E. B. Marengo, L. de Moraes, and R. L. Melo, “A Mycobacterium leprae Hsp65 mutant as a candidate for mitigating lupus aggravation in mice,” PLoS One, vol. 6, no. 9, Article ID e24093, 2011. View at Google Scholar
  18. E. Atherton and R. Sheppard, Solid Phase Peptide Synthesis—A Practical Approach, IRL Press, Oxford, UK, 1989.
  19. R. K. Agarwal, R. Horai, A. M. Viley et al., “Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due To reduced T cell priming and inhibition of disease effector mechanisms,” Journal of Immunology, vol. 180, no. 8, pp. 5423–5429, 2008. View at Google Scholar · View at Scopus
  20. J. S. Friedland, R. Shattock, D. G. Remick, and G. E. Griffin, “Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells,” Clinical and Experimental Immunology, vol. 91, no. 1, pp. 58–62, 1993. View at Google Scholar · View at Scopus
  21. Y. Ke, K. Liu, G. Q. Huang et al., “Anti-inflammatory role of IL-17 in experimental autoimmune uveitis,” Journal of Immunology, vol. 182, no. 5, pp. 3183–3190, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Amadi-Obi, C. R. Yu, X. Liu et al., “TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1,” Nature Medicine, vol. 13, no. 6, pp. 711–718, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Rajaiah, M. Puttabyatappa, S. K. Polumuri, and K. D. Moudgil, “Interleukin-27 and interferon-γ are involved in regulation of autoimmune arthritis,” Journal of Biological Chemistry, vol. 286, no. 4, pp. 2817–2825, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Ishida, K. Fukuda, T. Higuchi, M. Kajisako, S. Sakamoto, and A. Fukushima, “Dynamic changes of microRNAs in the eye during the development of experimental autoimmune uveoretinitis,” Investigative Ophthalmology and Visual Science, vol. 52, no. 1, pp. 611–617, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. A. G. Commodaro, J. P. S. Peron, C. T. Lopes et al., “Evaluation of experimental autoimmune uveitis in mice treated with FTY720,” Investigative Ophthalmology and Visual Science, vol. 51, no. 5, pp. 2568–2574, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. M. A. Toscano, A. G. Commodaro, J. M. Ilarregui et al., “Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses,” Journal of Immunology, vol. 176, no. 10, pp. 6323–6332, 2006. View at Google Scholar · View at Scopus
  27. R. Ulmansky, C. J. Cohen, F. Szafer et al., “Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion,” Journal of Immunology, vol. 168, no. 12, pp. 6463–6469, 2002. View at Google Scholar · View at Scopus