Table of Contents Author Guidelines Submit a Manuscript
Autoimmune Diseases
Volume 2012, Article ID 265823, 5 pages
http://dx.doi.org/10.1155/2012/265823
Research Article

Identification of TNIP1 Polymorphisms by High Resolution Melting Analysis with Unlabelled Probe: Association with Systemic Lupus Erythematosus

Jie Zhang,1,2,3 Yuewen Chen,1,3,4 Yong Shao,1,2,3 Qi Wu,1,3 Ming Guan,5 Wei Zhang,1,3 Jun Wan,3,6 and Bo Yu2

1Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen PKU-HKUST Medical Center, No. 1120 Lian-Hua Road, Futian District, Shenzhen, Guangdong 518036, China
2Department of Dermatology, Shenzhen Hospital, Peking University, Shenzhen, Guangdong 518036, China
3Biomedical Research Institute, Shenzhen PKU-HKUST Medical Center, No. 1120 Lianhua Road, Futian District, Shenzhen, Guangdong 518036, China
4JNU-HKUST Joint Laboratory, Jinan University, Guangdong 510632, China
5Department of Clinical Laboratory, Shanghai Worldwide Medical Center, Huashan 200040, China
6Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong

Received 6 March 2012; Accepted 31 May 2012

Academic Editor: Hiroshi Okamoto

Copyright © 2012 Jie Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. J. Edwards and C. Cooper, “Early environmental exposure and the development of lupus,” Lupus, vol. 15, no. 11, pp. 814–819, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. S. R. Block, J. B. Winfield, and M. D. Lockshin, “Studies of twins with systemic lupus erythematosus. A review of the literature and presentation of 12 additional sets,” American Journal of Medicine, vol. 59, no. 4, pp. 533–552, 1975. View at Google Scholar · View at Scopus
  3. R. R. Graham, G. Hom, W. Ortmann, and T. W. Behrens, “Review of recent genome-wide association scans in lupus,” Journal of Internal Medicine, vol. 265, no. 6, pp. 680–688, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. J. B. Harley, M. E. Alarcón-Riquelme, L. A. Criswell et al., “Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci,” Nature Genetics, vol. 40, no. 2, pp. 204–210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Hom, R. R. Graham, B. Modrek et al., “Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX,” The New England Journal of Medicine, vol. 358, no. 9, pp. 900–909, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. R. R. Graham, C. Cotsapas, L. Davies et al., “Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus,” Nature Genetics, vol. 40, no. 9, pp. 1059–1061, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. S. V. Kozyrev, A. K. Abelson, J. Wojcik et al., “Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus,” Nature Genetics, vol. 40, no. 2, pp. 211–216, 2008. View at Google Scholar · View at Scopus
  8. J. W. Han, H. F. Zheng, Y. Cui et al., “Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus,” Nature Genetics, vol. 41, no. 11, pp. 1234–1237, 2009. View at Google Scholar
  9. V. Gateva, J. K. Sandling, G. Hom et al., “A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus,” Nature Genetics, vol. 41, no. 11, pp. 1228–1233, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Yang, N. Shen, D. Q. Ye et al., “Genome-wide association study in asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus,” PLoS Genetics, vol. 6, no. 2, Article ID e1000841, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. C. F. He, Y. S. Liu, Y. L. Cheng et al., “TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population,” Lupus, vol. 19, no. 10, pp. 1181–1186, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. R. P. Nair, K. C. Duffin, C. Helms et al., “Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways,” Nature Genetics, vol. 41, no. 2, pp. 199–204, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. J. T. Elder, “Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis,” Genes and Immunity, vol. 10, no. 3, pp. 201–209, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Li and A. B. Begovich, “Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis,” Seminars in Immunology, vol. 21, no. 6, pp. 318–327, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Kawasaki, S. Ito, H. Furukawa et al., “Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study,” Arthritis Research & Therapy, vol. 12, no. 5, p. R174, 2010. View at Google Scholar · View at Scopus
  16. L. Verstrepen, I. Carpentier, K. Verhelst, and R. Beyaert, “ABINs: a20 binding inhibitors of NF-κB and apoptosis signaling,” Biochemical Pharmacology, vol. 78, no. 2, pp. 105–114, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Cohen, A. Ciechanover, Y. Kravtsova-Ivantsiv, D. Lapid, and S. Lahav-Baratz, “ABIN-1 negatively regulates NF-κB by inhibiting processing of the p105 precursor,” Biochemical and Biophysical Research Communications, vol. 389, no. 2, pp. 205–210, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. M. C. Hochberg, “Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 40, no. 9, p. 1725, 1997. View at Google Scholar · View at Scopus
  19. J. Montgomery, C. T. Wittwer, R. Palais, and L. Zhou, “Simultaneous mutation scanning and genotyping by high-resolution DNA melting analysis,” Nature Protocols, vol. 2, no. 1, pp. 59–66, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Y. Shi and L. He, “SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci,” Cell Research, vol. 15, no. 2, pp. 97–98, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. C. T. Wittwer, “High-resolution DNA melting analysis: advancements and limitations,” Human Mutation, vol. 30, no. 6, pp. 857–859, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. R. H. A. M. Vossen, E. Aten, A. Roos, and J. T. Den Dunnen, “High-resolution melting analysis (HRMA)—more than just sequence variant screening,” Human Mutation, vol. 30, no. 6, pp. 860–866, 2009. View at Publisher · View at Google Scholar · View at Scopus