Autoimmune Diseases

Research Article

A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts

Table 6

AChR-specific monoclonal antibodies.
MAb nameCross-react?Sequence
WF5NDVDEVNQIVET (67–76)
42, 176, 177, 203NDRLRQQWIDVRLRWNPADYGG (79–98)
28, 37, 42, 176, 177, 203Y RWNPADYGGIK (90–100)
6, 22, 47, 50, 198ND WNPAD
28, 35, 37, 42, 111, 203ND WNPADYGGIK
6, 198, 210ND WNPADYGGIKKIRLPSDD
WF6NDNNADGDFAIVHMTKLLLDYT (118–137)
WF6ND LDYTGKIMWTPPAIFKSYCE (134–153)
FK1ND WTPPAIFKSYCEIIVTHFPF
258ND YCEIIVTHFPFDQQNCT
5D9 (B-2-ADNR)Y**VRTVESGECTIQFFSNAAVTFGTAI (169–193)
236ND ESDRP
WF6ND PESDRPDLSTFMESGEWVMK (184–203)
A7ND VSISPESDRPDLSTF
WF6ND SISPESDRPDLSTFMESGEW
WF6NDNCTMKLGIWTYDGTKVSISP (165–184)
236, 237ND DGTKVSIS
A14ND LSTFMESGEWVMK (191–203)
A13ND SPESDRPDLSTFMESGE
4BND GWKHWV
9BND KHWVYY
31IY SGEWVMKDYRGWKHWVYYTCCPDTPYLDITYH
383CND WVYYTCCPDTPYL
370AND WVYYTCCPDTPYLDITYHF
WF6ND YRGWKHWVYYTCCPDTPYLD (205–224)
WF6ND WKHWVYYTCCPDTPYLDITY
3B ND YYTCCP
255ND DSGEKM
254, 255NDLPTDSGEK (259–266)
α304–322/1, α304–322/2ND RKIFIDTIPN
α304–322/3NDSTHTMPQWVRKIFIDTIPN (328–346)
10ND PSPDSKPT
117ND DSKPTIISRAN
169NDVTTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNAR (360–396)
110, 111, 112, 114, 118, 120, 123, 151Y NDEYFIRK
124, 148Y EYFIRK
5, 19, 142ND IDISDISGKQVTGEVIFQT (370–388)
3, 5ND SDISGKQVT
142ND GEVIFQ
142ND GKQVTGE (377–383)
149ND IFAD
13ND KIFADDID
187NDASKEKQENKIFADDIDISD (356–374)
149, 187ND NKIFADDI
A3ND NKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHM
61Y AIEGVKYI
152, 153, 157, 164ND DVKSAIEGVKYIAEH
8ND PDVKSAIEGV
155Y DVKSAIEG
10, 147ND VIFQTPLIKNP
8, 147, 153, 155, 164ND VIFQTPLIKNPDVKSAIEG (384–402)
147ND PLIKNPDVKSAI
152, 153, 155, 157, 164Y KSAIEGVK
61ND SAIEGVKYIAEHMKSDEESSN
147ND NPDVKSAI
8ND LIKNPDV
61NDIGTVSVFAGRLIELSQEG (444–461)
252ND GRLIELSQEG
7YRHGLKR (398–403)
154, 165, 168NDEYILKKPRS (380–388)
125NDQYVAMVADRLFLY (453–465)
145NDTSDIDI (408–413)
111, 148NDVDNARVAVQPERLFSEMKWHLNGLTQPVTLPQDLKEAVE (392–430)
6, 22, 35, 42, 47, 198NDN92, D95 (nonlinear)
637ND21–52, 80–101 (nonlinear)
These data were generated by performing an advanced B cell Search from the drop down menu. The epitope source antigen was selected, along with Qualitative Measurement equal to “positive” and Assayed Antibody Purification Status equal to “monoclonal.” This same search menu enables the user to search by mAb name if data captured for a specific monoclonal is desired. “Y”: the mAb was shown to cross-react with a human AChR; “ND”: not determined by assays present in the IEDB. **Cross-reacts with adrenergic receptor. Sequence positions given in parentheses were those provided by the authors.