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Autoimmune Diseases
Volume 2012, Article ID 404815, 6 pages
http://dx.doi.org/10.1155/2012/404815
Research Article

Significant Changes in the Levels of Secreted Cytokines in Brains of Experimental Antiphospholipid Syndrome Mice

1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
2Department of Neurology and Joseph Sagol Neuroscience Center, Sheba Medical Center, 52621 Ramat Gan, Israel
3Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel

Received 3 October 2011; Accepted 28 November 2011

Academic Editor: Jozélio Freire de Carvalho

Copyright © 2012 Assaf Menachem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. H. Rand, “Molecular pathogenesis of the antiphospholipid syndrome,” Circulation Research, vol. 90, no. 1, pp. 29–37, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. R. A. S. Roubey, C. W. Pratt, J. P. Buyon, and J. B. Winfield, “Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon β2-glycoprotein I,” Journal of Clinical Investigation, vol. 90, no. 3, pp. 1100–1104, 1992. View at Google Scholar · View at Scopus
  3. R. L. Brey, J. Chapman, S. R. Levine et al., “Stroke and the antiphospholipid syndrome: consensus meeting Taormina 2002,” Lupus, vol. 12, no. 7, pp. 508–513, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Ruiz-Irastorza, M. A. Khamashta, and G. R. V. Hughes, “Hughes syndrome crosses boundaries,” Autoimmunity Reviews, vol. 1, no. 1-2, pp. 43–48, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. A. E. Gharavi, L. R. Sammaritano, J. Wen, and K. B. Elkon, “Induction of antiphospholipid autoantibodies by immunization with β2 glycoprotein I (apolipoprotein H),” Journal of Clinical Investigation, vol. 90, no. 3, pp. 1105–1109, 1992. View at Google Scholar · View at Scopus
  6. A. Katzav, Y. Litvinjuk, C. G. Pick et al., “Genetic and immunological factors interact in a mouse model of CNS antiphospholipid syndrome,” Behavioural Brain Research, vol. 169, no. 2, pp. 289–293, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. A. Katzav, C. G. Pick, A. D. Korczyn et al., “Hyperactivity in a mouse model of the antiphospholipid syndrome,” Lupus, vol. 10, no. 7, pp. 496–499, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Shoenfeld, A. Nahum, A. D. Korczyn et al., “Neuronal-binding antibodies from patients with antiphospholipid syndrome induce cognitive deficits following intrathecal passive transfer,” Lupus, vol. 12, no. 6, pp. 436–442, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Shrot, A. Katzav, A. D. Korczyn et al., “Behavioral and cognitive deficits occur only after prolonged exposure of mice to antiphospholipid antibodies,” Lupus, vol. 11, no. 11, pp. 736–743, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Bakimer, P. Fishman, M. Blank, B. Sredni, M. Djaldetti, and Y. Shoenfeld, “Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3),” Journal of Clinical Investigation, vol. 89, no. 5, pp. 1558–1563, 1992. View at Google Scholar · View at Scopus
  11. P. Fishman, R. Bakimer, M. Blank, D. Sredni, M. Djaldetti, and Y. Shoenfeld, “The putative role of cytokines in the induction of primary anti-phospholipid syndrome in mice,” Clinical and Experimental Immunology, vol. 90, no. 2, pp. 266–270, 1992. View at Google Scholar · View at Scopus
  12. T. R. Mosmann and S. Sad, “The expanding universe of T-cell subsets: Th1, Th2 and more,” Immunology Today, vol. 17, no. 3, pp. 138–146, 1996. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Karakantza, G. L. Theodorou, N. Meimaris et al., “Type 1 and type 2 cytokine-producing CD4+ and CD8+ T cells in primary antiphospholipid syndrome,” Annals of Hematology, vol. 83, no. 11, pp. 704–711, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. P. Soltesz, H. Der, K. Veres et al., “Immunological features of primary anti-phospholipid syndrome in connection with endothelial dysfunction,” Rheumatology, vol. 47, no. 11, pp. 1628–1634, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. R. Forastiero, M. Martinuzzo, and L. O. Carreras, “Imbalance towards Th2-type response in patients with definite primary antiphospholipid syndrome,” Thrombosis and Haemostasis, vol. 86, no. 3, pp. 934–935, 2001. View at Google Scholar · View at Scopus
  16. D. Tanne, A. Katzav, O. Beilin et al., “Interaction of inflammation, thrombosis, aspirin and enoxaparin in CNS experimental antiphospholipid syndrome,” Neurobiology of Disease, vol. 30, no. 1, pp. 56–64, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. I. Krause, M. Blank, Y. Levi, T. Koike, V. Barak, and Y. Shoenfeld, “Anti-idiotype immunomodulation of experimental anti-phospholipid syndrome via effect on Th1/Th2 expression,” Clinical and Experimental Immunology, vol. 117, no. 1, pp. 190–197, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Napoleone, A. Di Santo, and R. Lorenzet, “Monocytes upregulate endothelial cell expression of tissue factor: a role for cell-cell contact and cross-talk,” Blood, vol. 89, no. 2, pp. 541–549, 1997. View at Google Scholar · View at Scopus
  19. M. P. Bevilacqua, J. S. Pober, G. R. Majeau, W. Fiers, R. S. Cotran, and M. A. Gimbrone Jr., “Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 12, pp. 4533–4537, 1986. View at Google Scholar
  20. G. Grignani and A. Maiolo, “Cytokines and hemostasis,” Haematologica, vol. 85, no. 9, pp. 967–972, 2000. View at Google Scholar · View at Scopus
  21. H. Groux and F. Cottrez, “The complex role of interleukin-10 in autoimmunity,” Journal of Autoimmunity, vol. 20, no. 4, pp. 281–285, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Yssel, R. D. W. Malefyt, M. G. Roncarolo et al., “IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells,” Journal of Immunology, vol. 149, no. 7, pp. 2378–2384, 1992. View at Google Scholar · View at Scopus
  23. K. Itoh and S. Hirohata, “The role of IL-10 in human B cell activation, proliferation, and differentiation,” Journal of Immunology, vol. 154, no. 9, pp. 4341–4350, 1995. View at Google Scholar · View at Scopus
  24. G. Girardi, J. Berman, P. Redecha et al., “Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome,” Journal of Clinical Investigation, vol. 112, no. 11, pp. 1644–1654, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. V. Michael Holers, G. Girardi, L. Mo et al., “Complement C3 activation is required for antiphospholipid antibody-induced fetal loss,” Journal of Experimental Medicine, vol. 195, no. 2, pp. 211–220, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Cacciola and S. Cordaro, “Anticomplement power of heparin,” Bollettino, Societa Italiana Biologia Sperimentale, vol. 33, no. 7, pp. 984–985, 1957. View at Google Scholar
  27. M. D. Kazatchkine, D. T. Fearon, D. D. Metcalfe, R. D. Rosenberg, and K. F. Austen, “Structural determinants of the capacity of heparin to inhibit the formation of the human amplification C3 convertase,” Journal of Clinical Investigation, vol. 67, no. 1, pp. 223–228, 1981. View at Google Scholar · View at Scopus
  28. G. Girardi, P. Redecha, and J. E. Salmon, “Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation,” Nature Medicine, vol. 10, no. 11, pp. 1222–1226, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus