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Autoimmune Diseases
Volume 2012, Article ID 453698, 3 pages
Review Article

Local Cartilage Trauma as a Pathogenic Factor in Autoimmunity (One Hypothesis Based on Patients with Relapsing Polychondritis Triggered by Cartilage Trauma)

Rheumatology Unit, Fundación Valle del Lili, ICESI University, Avenida Simón Bolívar Carrera 98 No.18-49, Cali, Colombia

Received 15 September 2011; Accepted 4 October 2011

Academic Editor: Juan-Manuel Anaya

Copyright © 2012 Carlos A. Cañas and Fabio Bonilla Abadía. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the recent years, it has been of great interest to study the binding mechanism between the innate and adaptive immune responses as interrelated processes for the development of multiple autoimmune diseases. Infection has been a well-known trigger of autoimmunity and trauma has been related as well too. Cryptogenic antigens release, recognition of pathogenic structure, and metabolic changes generated by both stimuli begin an inflammatory process which in turn activates the immune system amplifying T and B cell responses. The development of relapsing polychondritis after trauma may have a direct association with these events and in turn probably trigger autoimmune phenomena.