Review Article

Heat Shock Proteins: Pathogenic Role in Atherosclerosis and Potential Therapeutic Implications

Table 4

Summary of studies on potential heat shock protein-related treatments for various diseases.

StudyDiseaseSubjectsStudy summary and major findings

Maron et al. [74]AtherosclerosisMiceNasal vaccination with HSP65 resulted in a significant decrease in the size of atherosclerotic plaques, a reduced number of T cells, and an increased IL-10 expression
Harats et al. [75]AtherosclerosisMiceOral tolerance induced with HSP65 led to a reduction in atherosclerosis
Jun et al. [77]AtherosclerosisRabbitsVaccine targeting HSP65 and cholesterol ester transfer protein reduced low-density lipoprotein levels and atherosclerotic burden
Ishii et al. [80]Multiple myelomaHumanThe addition of an HSP90 inhibitor enhanced the antitumor activity of a proteasome inhibitor both in vitro and in vivo
Kaiser et al. [81]Acute leukemiaHumanHSP70 inhibitor displayed antileukemic effects both alone and in combination with other antineoplastic agents