Association of HLA-DQB1*05:02 and DRB1*16 Alleles with Late-Onset, Nonthymomatous, AChR-Ab-Positive Myasthenia Gravis

Table 2

HLA class II allele frequency analysis in the LOAb-MG patients subgroup.

Alleles	Healthy controls		Patients			Statistical analysis
	𝑛	Allelic frequencies	𝑛	Allelic frequencies	OR	95% CI	𝑃	𝑃𝑐
HLA-DRB1
*01	15	0.075	6	0.111			NS
*015	16	0.080	4	0.074			NS
*016	7	0.035	9	0.167	5.5143	1.0407–15.596	0.0016	0.0211
*03	22	0.110	1	0.019			NS
*04	18	0.090	6	0.111			NS
*011	56	0.280	9	0.167			NS
*012	3	0.015	0	0.000			NS
*013	21	0.105	1	0.019			NS
*014	9	0.045	7	0.130			NS
*07	21	0.105	10	0.185			NS
*08	8	0.040	0	0.000			NS
*09	1	0.005	0	0.000			NS
*10	3	0.015	1	0.019			NS
Total alleles	200	1	54	1
HLA-DQB1
*02	39	0.195	9	0.167			NS
*03	85	0.425	17	0.315			NS
*04	8	0.040	0	0.000			NS
*05:01	18	0.090	6	0.111			NS
*05:02	8	0.040	10	0.185	5.4545	2.0354–14.617	0.0009	0.00768
*05:03	9	0.045	7	0.130			NS
*05:04	0	0.000	0	0.000			NS
*06	33	0.165	5	0.093			NS
Total alleles	200	1	54	1