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Autoimmune Diseases
Volume 2012, Article ID 812138, 6 pages
http://dx.doi.org/10.1155/2012/812138
Clinical Study

Screening Tests of Reproductive Immunology in Systemic Lupus Erythematosus

1Department of Obstetrics and Gynecology, Faculty of Medicine in Pilsen and University Hospital, University in Pilsen, 30460 Pilsen, Czech Republic
2Department of Neonatology, Faculty of Medicine in Pilsen and University Hospital, Charles University in Prague, Alej Svobody 80, 30460 Pilsen, Czech Republic
3Institute of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, Karlovarská 48, 30166 Pilsen, Czech Republic

Received 13 June 2012; Revised 30 September 2012; Accepted 30 September 2012

Academic Editor: Hiroshi Okamoto

Copyright © 2012 Zdenka Ulcova-Gallova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Female patients in reproductive age with systemic lupus erythematosus and fertility complications together are observed by rheumatologists, gynecologists, and reproductive immunologists. The paper notes the presence of autoantibodies to zona pellucida, to phospholipids (phosphatidyl serine, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl glycerol, phosphatidic acid, annexin V, beta-2 glycoprotein I, and cardiolipin) and of isoantibodies to sperm cells. Isoantibodies to sperm cells are not significantly predominant, but autoimmunity is well expressed in IgG positivity against phosphatidyl inositol, phosphatidyl ethanolamine, phosphatidyl serine, cardiolipin, and beta-2 glycoprotein I, as well as antizona pellucida antibodies in IgG isotype. According to the levels of autoantibodies we have to choose preventive treatment to protect mother and her foetus.