DNA Damage in Rheumatoid Arthritis: An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine
Chemical structures of DNA adducts and their corresponding peaks detected by LC-MS/MS. (a) Chemical structures of the DNA adducts 8-oxo-hydroxy-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG), 1,N6-etheno-2′-deoxyadenosine (εdA), and heptanone-etheno-2′-deoxycytidine (HεdC). (b) DNA adducts were quantified by calculating the ratio of the peak of the DNA adduct to that of its standard isotope. The respective peaks of the standard isotope and the corresponding sample are shown.