DNA Damage in Rheumatoid Arthritis: An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine
HεdC levels are significantly elevated in RA patients. (a) The respective median (range) values of HεdC from RA patients and controls were 10.3 (0.3–119) and 0.33 (0.3–17.8) per 109 bases. HεdC levels in RA patients were thus significantly higher than in controls (). The straight and dotted line represent linear approximation of the values of HεdC versus age from RA patients and controls. (b) The geographic mean level of HεdC increased with aging in RA patients ().