Immunosenescence, Aging, and Systemic Lupus Erythematous

Figure 4

Aged-related functional changes in T-cell subsets. Alterations are produced in both memory and naïve subsets. These alterations depend on T-cell microenvironmental history, exposures to stressor agents, and stochastic events. There are differences in changes between CD4⁺ and CD8⁺ concerning aging, but in both cases, there is reduction of naïve subtype, increase in lifespan, and defective immune response.