Autoimmune Diseases

Research Article

Posttranslational Protein Modification in the Salivary Glands of Sjögren’s Syndrome Patients

Table 1

Clinical, serologic, and immunohistochemistry data.
  Sjögren ( )  Controls ( )  
Clinical data       
 Sicca  24 (8 = IV, 5 = III, 6 = II, 5 = I)  0  * P < 0.0001
 Glandular 24 (8 = IV, 5 = III, 6 = II, 5 = I)  0  * P < 0.0001
 Extraglandular 10 (8 = IV, 2 = III)  0  * P < 0.0006
Serology       
 Anti-CCP 2 (2 = IV)  0  * P < 0.4890
 +RF 10 (8 = IV, 2 = III)  0  * P < 0.0006
 +ANA 16 (8 = IV, 5 = III, 3 = II)  0  * P < 0.0001
 +Anti-La 12 (7 = IV, 4 = III, 1 = II)  0  * P < 0.0025
 +Anti-Ro 14 (8 = IV, 4 = III, 1 = II, 1 = I)  0  * P < 0.0001
Biopsies       
 AciniDuctsInfiltratesAciniDuctsInfiltrates 
PAD 217
£(8 = IV, 6 = III, 2 = II, 1 = I)		17
£(8 = IV, 6 = III, 2 = II, 1 = I)		12
£(8 = IV, 4 = III)		020 * P < 0.0001
CCP17
£(8 = IV, 5 = III, 3 = II, 1 = I)		17
£(8 = IV, 5 = III, 3 = II, 1 = I)		17
£(8 = IV, 5 = III, 3 = II, 1 = I)		000 * P < 0.0001
Citrulline19
£(8 = IV, 5 = III, 5 = II, 1 = I)		19
£(8 = IV, 5 = III, 5 = II, 1 = I)		17
£(8 = IV, 5 = III, 3 = II, 1 = I)		020 * P < 0.0001
Sjögren versus controls.
Sjögren class IV versus class I = P < 0.003.
Histology class inside the parentheses.