Lower Serum Androstenedione Levels in Pre-Rheumatoid Arthritis versus Normal Control Women: Correlations with Lower Serum Cortisol Levels

Table 3

Age-adjusted, log-normalized correlations (Pearson) of total female pre-RA (top) and CN (bottom) hormone levels*.

Hormones		Preg	Prog	17-OHpreg	17-OHprog	DHEA	Adione	Test	Estradiol	Estrone	Cmpd B	DeoxyCort	Cortisol	DHEAS
Preg	𝑟		0.532	0.149	0.476	0.025	0.163	−0.195	0.305	−0.081	0.097	0.430	−0.011	0.085
	𝑝		0.003	0.432	0.008	0.898	0.417	0.310	0.122	0.794	0.611	0.018	0.954	0.657
	𝑛		30	31	31	29	28	30	28	14	31	31	31	31
Prog	𝑟	0.516		0.301	0.681	0.071	0.162	−0.512	0.266	0.021	0.122	0.349	−0.200	0.248
	𝑝	0.000		0.113	0.000	0.726	0.428	0.005	0.189	0.947	0.491	0.043	0.258	0.158
	𝑛	111		30	30	28	27	29	27	14	35	35	35	35
17-OHpreg	𝑟	0.392	0.315		0.629	0.785	0.666	0.061	0.264	0.273	0.203	0.194	0.074	0.419
	𝑝	0.000	0.001		0.000	0.000	0.000	0.753	0.184	0.366	0.281	0.305	0.696	0.021
	𝑛	111	111		31	29	28	30	28	14	31	31	31	31
17-OHprog	𝑟	0.529	0.681	0.724		0.344	0.452	−0.381	0.367	−0.071	0.046	0.400	−0.237	0.274
	𝑝	0.000	0.000	0.000		0.074	0.018	0.041	0.060	0.817	0.809	0.028	0.207	0.142
	𝑛	111	111	111		29	28	30	28	14	31	31	31	31
DHEA	𝑟	0.126	0.021	0.624	0.419		0.643	0.173	0.136	0.251	0.274	0.228	0.184	0.489
	𝑝	0.199	0.828	0.000	0.000		0.000	0.377	0.518	0.457	0.158	0.244	0.350	0.008
	𝑛	107	107	107	107		28	29	26	12	29	29	29	29
Adione	𝑟	0.163	0.075	0.427	0.357	0.762		0.014	0.542	0.216	0.506	0.328	0.174	0.625
	𝑝	0.093	0.443	0.000	0.000	0.000		0.944	0.006	0.524	0.007	0.094	0.384	0.000
	𝑛	108	108	108	108	107		28	25	12	28	28	28	28
Test	𝑟	−0.01	−0.254	0.256	−0.047	0.411	0.306		−0.18	−0.123	0.036	0.042	0.049	0.009
	𝑝	0.922	0.010	0.009	0.638	0.000	0.002		0.380	0.704	0.852	0.830	0.800	0.962
	𝑛	103	103	103	103	102	103		27	13	30	30	30	30
Estradiol	𝑟	0.264	0.281	0.196	0.363	0.112	0.204	0.00		0.485	0.485	0.213	0.462	0.120
	𝑝	0.008	0.004	0.049	0.000	0.273	0.044	0.999		0.093	0.011	0.285	0.015	0.550
	𝑛	102	102	102	102	98	99	94		14	28	28	28	28
Estrone	𝑟	0.127	0.077	−0.191	−0.136	−0.044	−0.01	−0.011	0.323		0.033	−0.403	0.387	−0.087
	𝑝	0.361	0.579	0.167	0.327	0.761	0.943	0.941	0.017		0.914	0.172	0.191	0.778
	𝑛	55	55	55	55	51	52	47	55		14	14	14	14
Cmpd B	𝑟	0.267	0.133	0.176	0.078	−0.076	0.027	0.048	0.025	−0.074		0.510	0.579	0.21
	𝑝	0.005	0.117	0.065	0.416	0.441	0.786	0.629	0.802	0.594		0.002	0.000	0.227
	𝑛	111	141	111	111	107	108	103	102	55		36	36	36
DeoxyCort	𝑟	0.270	0.195	0.100	0.119	−0.013	0.010	0.024	0.288	0.007	0.517		−0.064	0.178
	𝑝	0.004	0.021	0.301	0.214	0.895	0.921	0.808	0.003	0.959	0.000		0.713	0.306
	𝑛	111	141	111	111	107	108	103	102	55	143		36	36
Cortisol	𝑟	−0.026	−0.126	0.131	−0.121	0.089	−0.001	0.028	−0.273	0.047	0.295	−0.053		−0.081
	𝑝	0.785	0.139	0.173	0.206	0.366	0.991	0.777	0.006	0.738	0.000	0.528		0.644
	𝑛	111	141	111	111	107	108	103	102	55	143	143		36
DHEAS	𝑟	0.228	0.074	0.334	0.217	0.460	0.404	0.089	0.087	0.088	0.034	0.039	−0.061
	𝑝	0.017	0.388	0.000	0.022	0.000	0.000	0.373	0.385	0.525	0.687	0.642	0.473
	𝑛	111	141	111	111	107	108	103	102	55	143	143	143

∗No significant difference found between pre-RA versus CN correlations, when also requiring set-specific Z-score values for combining assay results in study subjects.