B Lymphocytes: Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus

<table>BAFF and APRIL receptors. BAFF binds chiefly to BAFF-R (BR3) but also to BCMA and TACI. APRIL, in turn, interacts with TACI and BCMA, but not with BR3. In addition, APRIL binds to proteoglycans expressed in membranes of lymphoid and nonlymphoid cells. </table>

Autoimmune Diseases

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Figure 7

Figure 7: B Lymphocytes: Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus 