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Autoimmune Diseases
Volume 2013, Article ID 834295, 5 pages
Clinical Study

Pemphigus Vulgaris and Infections: A Retrospective Study on 155 Patients

1Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran 1199663911, Iran
2Department of Dermatology, Tehran University of Medical Sciences, Tehran 1199663911, Iran
3Razi Hospital, Vahdat Islamic Square, Tehran 1199663911, Iran
4Infectious Diseases Specialist, Razi Hospital, Tehran University of Medical Sciences, Tehran 1199663911, Iran
5Sharif University of Technology, Tehran 1136511155, Iran
6Islamic Azad University, Tehran Medical Branch, Tehran 193951495, Iran

Received 29 March 2013; Revised 19 May 2013; Accepted 2 June 2013

Academic Editor: Jozélio Freire de Carvalho

Copyright © 2013 Nafiseh Esmaili et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Autoimmune process and immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. Aim. We aimed to study the prevalence of infection and pathogenic agents in pemphigus vulgaris patients admitted to dermatology service. Material and methods. This retrospective study was conducted on 155 pemphigus vulgaris patients (68 males, 87 females) admitted to dermatology service between 2009 and 2011. In this study, the diagnosis of pemphigus vulgaris was confirmed by light microscopic and direct immunofluorescence findings. Data were collected through a questionnaire. Results. Of 155 pemphigus vulgaris patients, 33 had infection at admission and 9 acquired nosocomial infection. In addition, 37 cases of oral candidiasis and 15 cases of localized herpes simplex were recorded. Totally, 94 cases of infection were recorded. The occurrence of infection was significantly related to the severity of disease, number of hospital admissions, and presence of diabetes mellitus. The most common pathogenic germs isolated from cultures were Staphylococcus aureus and Escherichia coli. Conclusion. Severity of pemphigus vulgaris and diabetes were directly related with tendency to infections. Staphylococcus aureus and Escherichia coli were the most common pathogenic agents. Due to limitations of retrospective study, a prospective study is recommended.