TY - JOUR A2 - Anaya, Juan-Manuel AU - Cozzani, Emanuele AU - Drosera, Massimo AU - Gasparini, Giulia AU - Parodi, Aurora PY - 2014 DA - 2014/02/06 TI - Serology of Lupus Erythematosus: Correlation between Immunopathological Features and Clinical Aspects SP - 321359 VL - 2014 AB - Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the aberrant production of a broad and heterogenous group of autoantibodies. Even though the presence of autoantibodies in SLE has been known, for more than 60 years, still nowadays a great effort is being made to understand the pathogenetic, diagnostic, and prognostic meaning of such autoantibodies. Antibodies to ds-DNA are useful for the diagnosis of SLE, to monitor the disease activity, and correlate with renal and central nervous involvements. Anti-Sm antibodies are highly specific for SLE. Anti-nucleosome antibodies are an excellent marker for SLE and good predictors of flares in quiescent lupus. Anti-histone antibodies characterize drug-induced lupus, while anti-SSA/Ro and anti-SSB/La antibodies are associated with neonatal lupus erythematosus and photosensitivity. Anti-ribosomal P antibodies play a role in neuropsychiatric lupus, but their association with clinical manifestations is still unclear. Anti-phospholipid antibodies are associated with the anti-phospholipid syndrome, cerebral vascular disease, and neuropsychiatric lupus. Anti-C1q antibodies amplify glomerular injury, and the elevation of their titers may predict renal flares. Anti-RNP antibodies are a marker of Sharp’s syndrome but can be found in SLE as well. Anti-PCNA antibodies are present in 5–10% of SLE patients especially those with arthritis and hypocomplementemia. SN - 2090-0422 UR - https://doi.org/10.1155/2014/321359 DO - 10.1155/2014/321359 JF - Autoimmune Diseases PB - Hindawi Publishing Corporation KW - ER -