Autoimmune Diseases / 2014 / Article / Tab 1 / Research Article
A Comparison of Anti-Nuclear Antibody Quantification Using Automated Enzyme Immunoassays and Immunofluorescence Assays Table 1 Clinical diagnoses and results of EIA and IFA. The combined results of anti-dsDNA, ANA screening, and the seven individual antigens are referred to as “EIA-combined.” The IFA classification was based on the results from the primary laboratory and (if performed) from the secondary laboratory.
Diagnosis dsDNA EIA ANA screen EIA EIA-combined IFA NEG EQV POS NEG EQV POS NEG EQV POS NEG EQV POS ANA-associated disease (
, 18%) 38 2 4 26 2 16 28 1 15 28 2 14 SLE (
) 5 3 4 1 3 4 4 4 4 Juvenile RA (
) 8 7 1 8 6 1 1 Raynaud (
) 5 2 3 3 2 4 Vasculitis (
) 5 4 1 5 5 Autoimmune hepatitis (
) 3 1 2 2 2 2 3 1 Dermatomyositis/polymyositis (
) 3 3 3 3 Scleroderma (
) 3 1 2 1 2 1 2 UCTD (
) 2 1 2 1 1 1 1 3 MCTD (
) 2 1 3 3 3 Discoid lupus (
) 2 1 1 1 1 2 Non-ANA-associated disease (
, 46%) 150 2 5 149 5 3 149 2 7 137 12 8 Rheumatoid arthritis (
) 46 2 44 2 2 44 4 36 9 3 Back pain (
) 34 2 34 2 34 2 35 1 Arthritis (
) 32 1 1 32 1 1 32 1 1 29 1 4 Osteoarthrosis (
) 13 13 13 13 Polymyalgia rheumatica (
) 10 1 11 10 1 10 1 Arthralgia/myalgia (
) 7 7 7 7 Ankylosing spondylitis (
) 5 5 5 4 1 Giant cell arthritis (
) 3 3 3 3 Other diseases (
, 36%) 177 2 6 168 8 9 166 5 14 169 8 8 Neurological disorder (
) 53 56 2 52 1 5 56 2 Miscellaneous (
) 50 44 3 3 46 1 3 43 4 3 Malignancy (
) 13 12 1 12 13 Renal disorder (
) 11 1 12 11 1 12 Osteoporosis (
) 11 1 9 1 2 9 1 2 9 1 2 Inflammatory bowel disease (
) 10 10 10 9 1 Infection (
) 10 10 10 9 Liver disease (
) 8 1 8 1 8 1 9 Vitamin D deficiency (
) 5 1 4 2 3 3 1 1 Lung disease (
) 4 4 4 4 Endocrine disorder (
) 2 2 2 2 All (
) 365 6 15 343 15 28 342 8 36 334 22 30
NEG: negative; EQV: equivocal; and POS: positive; MCTD: mixed connective tissue disease; RA: rheumatoid arthritis; SLE: systemic lupus erythematosus; and UCTD: undifferentiated connective tissue disease.
