Autoimmunity and Asbestos Exposure

Table 3

Animal model studies of asbestos and autoimmunity.

Reference	Strain (all inbred)	Disease model	Sex used	Treatment (fiber, route, duration)	Notes
Ferro et al., 2013 [39]	C57BL/6 mice	None	Female	LA, Chry, i.t., 7 mo.	LA (not Chry) increased; ANA and IL-17
Pfau et al., 2008 [40]	C57BL/6 mice	None	Female	LA, i.t., 7 mo.	LA increased ANA, anti-Ro52, anti-dsDNA, IC
Salazar et al., 2012 [41]	Lewis rat	None	Female	LA, amosite, i.t., 13 weeks	Both increase ANA, anti-Jo-1.; No IC, no anti-dsDNA
Salazar et al., 2012 [42]	Lewis rat	Antigen-induced arthritis (CIA, PG-PS)	Female	LA, amosite, i.t., 13 weeks	Both fibers increase ANA; no exacerbated disease
Pfau et al., 2011 [43]	C57BL/6 mice	None	Female	LA, tremolite, i.t., 7 mo.	Both induced antifibroblast antibodies

LA: Libby amphibole; ANA: antinuclear antibodies; Chry: chrysotile; i.t.: intratracheal; CIA: collage-induced arthritis; PG-PS: peptidoglycan/polysaccharide induced arthritis; IC: immune complexes in kidneys. Amosite and tremolite are both amphiboles.