Exploring T Cell Reactivity to Gliadin in Young Children with Newly Diagnosed Celiac Disease
Table 2
Proliferative responses to - and -gliadin epitopes.
Epitope
Amino acid sequence*
Proliferation response**
Native -gliadin
SGQGSFQPSQQNP
1/10 (10%)
-Gliadin p1E
SGEGSFQPSQQNP
6/10 (60%)
-Gliadin p9E
SGQGSFQPSQ ENP
2/10 (20%)
-Gliadin p1E, p9E
SGEGSFQPSQ ENP
0/10 (0%)
-I-Gliadin
QLQPFPQP ELPY
3/10 (30%)
-II-Gliadin
PQP ELPYPQPQL
0/10 (0%)
Native -gliadin
FPQQPQQPYPQQPQQ
0/10 (0%)
-Gliadin p1E
FPEQPQQPYPQQPQQ
1/10 (10%)
-Gliadin p9E
FPQQPQQPYP EQPQQ
0/10 (0%)
-Gliadin p1E, p9E
FPEQPQQPYP EQPQQ
2/10 (20%)
-I-Gliadin
PEQPQQSFP EQERP
0/10 (0%)
Glutamic acid (E) residues in bold are formed by tissue transglutaminase mediated deamidation. Underlined residues form the MHC class II peptide binding register.
stimulation index ≥ 3 is considered a response.