Differential Immunotoxicity Induced by Two Different Windows of Developmental Trichloroethylene Exposure

Table 2

Gene expression in CD4⁺ T cells from mice exposed to TCE during gestation or early life.

	Early life			Gestation
	Control	TCE 0.01	TCE0.1	Control	TCE 0.01	TCE 0.1
Iap	1.0±0.17	𝟎.𝟏𝟐±𝟎.𝟎𝟐	0.42±0.36	1.00±0.1	𝟎.𝟒𝟑±𝟎.𝟎𝟓	𝟎.𝟕𝟐±𝟎.𝟏𝟗
Muerv	0.95±0.26	𝟎.𝟔±𝟎.𝟏𝟏	0.76±0.23	1.0±0.15	𝟎.𝟒𝟒±𝟎.𝟎𝟒	0.95±0.26
Il2	1.0±0.1	𝟏.𝟒𝟗±𝟎.𝟐	𝟏.𝟑𝟏±𝟎.𝟏	0.91±0.1	0.97±0.29	𝟎.𝟔𝟔±𝟎.𝟏
Il4	1.0±0.17	1.1±0.35	1.4±0.34	1.1±0.43	1.47±0.75	1.44±0.93
Cdkn1a	1.0±0.03	0.9±0.07	0.92±0.07	1.05±0.38	1.62±0.64	1.41±1.1
Ifng	0.91±0.16	0.95±0.11	𝟏.𝟑𝟏+𝟎.𝟐𝟐	1.32±1.0	1.0±0.81	1.42±1.11
Dnmt1	1.0±0.24	1.05±0.12	0.89±0.22	1.11±0.51	1.58±0.36	1.73±0.71
Dnmt3a	0.98±0.02	1.08±0.07	1.09±0.07	0.98±0.51	1.12±0.35	1.2±0.87

Gene expression was examined in splenic CD4⁺ T cells incubated with anti-CD3 and anti-CD28 Abs for 24 hours following isolation from untreated control mice or from mice exposed to TCE during gestation only, or during early life only. The data represents the mean ± SD. *Significantly different (𝛼<0.05) compared to control values.
The bolded text represents values that are significantly different from control values (𝛼<0.05).