The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL/6 and BALB/C Mice

Figure 2

Gene expression of immunomodulatory molecules: (a) H2-Q7 (Qa-2/HLA-G); (b) H2-T23 (Qa-1/HLA-E); (c) AIRE; and (d) FOXP3 in thymus of C57BL/6 mice inoculated with 10.000 LD₅₀ of YFV17D or PBS. RQ = relative quantification representative of geometric mean values of . Tissue samples were obtained in triplicate from different animals for each treatment. Each experiment was independently performed at least three times. Statistical analysis was performed using the nonparametric test Mann-Whitney two-tailed. Values close to the level of significance () are marked with .

(a)

(b)

(c)

(d)