Table of Contents Author Guidelines Submit a Manuscript
Autoimmune Diseases
Volume 2015, Article ID 503087, 12 pages
http://dx.doi.org/10.1155/2015/503087
Research Article

The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL/6 and BALB/C Mice

1Division of Clinical Immunology, Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil
2Commissariat à l’Energie Atomique et aux Energies Alternatives, Institut des Maladies Emergentes et des Thérapies Innovantes, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, Bâtiment Lailler, 75475 Paris Cedex 10, France
3Université Paris-Diderot, Sorbonne Paris-Cité, UMR E5, Institut Universitaire d’Hématologie, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
4Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil

Received 25 June 2015; Revised 17 August 2015; Accepted 26 August 2015

Academic Editor: Xu-Jie Zhou

Copyright © 2015 Breno Luiz Melo-Lima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The morphological analysis of internal organs in YFV17D - immunized animals revealed liver and spleen hypertrophy at Day 7 a.i in BALB/c mice compared to C57BL/6 and compared to control groups. (Supplemental data I). The gene expression analysis of H2-Q10(Qa10) in thymus of C57BL/6 and BALB/c mice inoculated with 10.000 LD50 of YFV17D or PBS showed no differences in H2-Q10(Qa10) transcription compared to the control group. (Supplemental data II). Increased transcript levels of H2-Q10(Q10) were observed in the liver of YFV17D-treated C57BL/6 mice compared to thymus and spleen (P<0.05). (Supplemental data III).

  1. Supplementary Material