Research Article

Detection of Antibodies against Human and Plant Aquaporins in Patients with Multiple Sclerosis

Table 1

Measurement of antibodies against MBP, MOG, S100B, human AQP4, soy AQP4, corn AQP4, tomato AQP4, and spinach AQP4 in controls (C) and patients (P) with RRMS expressed by ELISA optical densities and mean ± SD.

MBP (OD)MOG (OD)S100B (OD)Human AQP4 (OD)Soy AQP4 (OD)Corn AQP4 (OD)Tomato AQP4 (OD)Spinach AQP4 (OD)
CPCPCPCPCPCPCPCP

IgGLow0.190.310.060.310.200.310.160.310.050.240.170.150.050.230.170.26
High1.432.201.152.181.332.441.972.281.132.841.312.261.132.731.452.44
Mean ±0.751.070.550.910.671.040.811.020.541.070.691.080.521.020.761.15
±0.25±0.49±0.23±0.45±0.25±0.51±0.36±0.5±0.24±0.57±0.26±0.53 ±0.26±0.56±0.28±0.48
value<0.0001<0.0001<0.00010.0093<0.0001<0.0001<0.0001<0.0001

IgALow0.130.120.120.100.140.110.210.290.130.130.220.260.130.150.060.27
High1.053.720.932.981.182.992.013.351.013.361.332.981.032.561.733.04
Mean ±0.610.940.550.870.570.850.671.110.490.760.660.960.500.810.620.96
±0.23±0.71±0.19±0.51±0.23±0.58±0.34±0.68±0.20±0.54±0.30±0.57±0.20±0.52±0.31±0.58
value0.0015<0.00010.0015<0.00010.00080.00090.00010.0003

IgMLow0.160.480.060.550.050.380.170.420.060.350.140.350.050.360.160.61
High1.132.881.373.401.253.521.402.761.183.531.803.391.162.901.493.58
Mean ±0.631.160.641.410.621.190.761.180.531.070.711.340.611.150.821.52
±0.25±0.61±0.28±0.79±0.25±0.74±0.29±0.57±0.22±0.70±0.32±0.76±0.23±0.60±0.33±0.76
value<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001