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| Medication | Recommendation for pregnancy planning | Indication
during pregnancy | FDA 1979 class | Comment for using during pregnancy | Maternal adverse reactions | Fetal/neonatal adverse reactions | Lactation |
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| Aspirin (low dose) | Start before conception | Obstetric APS | B/C | 80–100 mg/d used isolated or in combination with LMWH | Bleeding | No | Allowed |
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| Azathioprine | Without stopping | Used in cases requiring immunosuppression and to save corticoid | D | 1–2,5 mg/Kg/d | Liver toxicity and bone marrow toxicity | No | Allowed |
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| Belimumab | Not start during pregnancy
Not stop during pregnancy | Arthritis, other inflammatory | C | 10 mg/kg IV q2 weeks ×3 doses,
Maintenance: 10 mg/kg IV q4 weeks | Reactivation of tuberculosis | No | Not allowed |
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| Cyclosporine A | | | C | Blood pressure monitor | Increase of blood pressure | Low birth weight | Not allowed |
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| Cyclophosphamide | Stop > 6 months before conception | Not allowed | X | | | | Not allowed |
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| Fluorinated corticosteroids | It will be used in more advanced pregnancy | NLE and maturity of fetal lungs | B | Use betamethasone 12 mg/d for two days | Uncontrolled glycemic | No | Allowed |
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| Hydroxychloroquine | Keep the drug to prevent reactivation of lupus | Lupus, arthritis | N | 200–400 mg/d | Maternal skin hyperpigmentation | No | Allowed |
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| Leflunomide | Stop 3–6 months before conception | Not allowed | X | | | | Not allowed |
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| Low-molecular weight heparin | Generally used | Obstetric APS | C | Used in prophylactic dose of 0.5 mg/Kg QID for OBAPS and in full dose 1 mg/Kg BID for thrombotic APS | Osteoporosis, thrombocytopenia | No | Allowed |
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| NSAID | Avoid since it may decrease | Arthritis, other inflammatory | C/D | Avoid in the 3rd trimester | Gastric bleeding | Premature closure of the ductus arteriosus, oligohydramnios | Allowed |
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| Methotrexate | Stop 3–6 months before conception | Not allowed | X | | | | Not allowed |
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| Mycophenolate mofetil | Stop before conception | Not allowed | X | | | | Not allowed |
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| Prednisone/prednisolone | Try to minimize dose due to maternal AEs | Lupus, arthritis, other inflammatory diseases | C | Inactivated in the placenta, minimize dose due to maternal AEs | Increase of blood pressure, osteopenia, gestational diabetes, immunosuppression, grooves. | Cleft lip sporadically Low birth weight
Premature birth | Allowed (if more than 40 mg, wait for 3 hours) |
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| Rituximab | Not start during pregnancy
Not stop during pregnancy | Arthritis, other inflammatory | C | 375 mg/m²/IV q4 weeks | Reactivation of tuberculosis | No | Not allowed |
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| Statins | Stop before conception | Not allowed | X | | | | Not Allowed |
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| ACEi | Stop before conception | Not allowed | D | | | Fetal death, renal dysfunction and oligohydramnios | Allowed |
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| Tacrolimus | | Used in cases requiring immunosuppression | C | 0,1–0,2 mg/kg/d | Diabetes, increase of blood pressure, reactivation of tuberculosis | Increase of blood pressure, diarrhea, headache, renal dysfunction | Not allowed |
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| Warfarin | Stop at conception | Not allowed | X | | | | Allowed |
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