Thrombosis and Anticoagulation Therapy in Systemic Lupus Erythematosus

Figure 1

When endothelial cells are damaged by autoantibodies (ANCA,AECA,APL) and neutrophil extracellular traps, collagen and TF are exposed to the circulating blood, which the coagulation cascade is activated. Circulating platelets adhere directly to collagen via glycoprotein Ia/IIa surface receptors. This adhesion is further enhanced by the release of von Willebrand factor (vWF) from the damaged vascular endothelium and activated platelets. These interactions further activate platelets,which ultimately lead to increased platelet aggregation and thrombosis.