Autoimmune Diseases

Environmental Triggers and Autoimmunity


Publishing date
13 Jun 2014
Status
Published
Submission deadline
24 Jan 2014

Lead Editor

1Immunosciences Lab., Inc., Los Angeles,. CA, USA

2Department of Medicine, Division of Rheumatology and Immunology, Department of Medicine USC, USC, Los Angeles, CA, USA

3Dept.artment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA


Environmental Triggers and Autoimmunity

Description

During the past decades a significant increase in the incidence of autoimmune disease has been observed worldwide. Autoimmunity arises when the host’s immune system is directed against self-tissue antigens. Accumulating evidence has suggested a close interplay between genetic factors and environmental triggers such as infections, toxicants and some dietary components in the pathogenesis of autoimmune diseases. Consequently, since 1997 research and publications devoted to environmental triggers in autoimmunity has grown by an average of 7% every year.

The mechanisms by which environmental factors induce autoimmunity has been described variously as involving cross-reactivity, aberrant cell death, or the binding of toxicants to tissue proteins with the subsequent formation of neoantigens. To optimize the chances of therapeutic success, it is essential to first identify the environmental triggers and then remove them from the patient’s environment.

We invite researchers to contribute original and review articles that will focus on the roles that environmental triggers play in various autoimmune disorders. Potential topics include, but are not limited to:

  • Epigenetics of environmentally induced autoimmune disorders
  • Epidemiology of environmentally induced autoimmunity
  • Assessment of the impact of environmental factors on autoimmunity
  • Innate and adaptive immunity in the etiology of environmentally induced autoimmunity
  • Mechanisms of environmental (infections, toxic chemicals, and dietary proteins) influences on human autoimmunity
  • The roles of Th1, Th3, Th17, and B-cell activation in environmentally induced autoimmune disease
  • Modification of self-antigens by acetylation, lipidation, citrullination, and glycosylation induced by environmental factors in autoimmune diseases
  • Detection of antibodies against different environmental triggers for very early detection of autoimmune reactivities
  • Antibodies and other immune markers for the early detection of autoimmune disease
  • The role of diet modification and lifestyle changes in the improvement of autoimmune conditions (gluten-free diet and gluten sensitivity/celiac disease is only one example
  • The role of gut microbiota in the development of autoimmune diseases

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/ad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ad/trigg/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 798029
  • - Editorial

Environmental Triggers and Autoimmunity

Aristo Vojdani | K. Michael Pollard | Andrew W. Campbell
  • Special Issue
  • - Volume 2014
  • - Article ID 340875
  • - Review Article

Neuroantibody Biomarkers: Links and Challenges in Environmental Neurodegeneration and Autoimmunity

Hassan A. N. El-Fawal
  • Special Issue
  • - Volume 2014
  • - Article ID 152428
  • - Review Article

Autoimmunity and the Gut

Andrew W. Campbell
  • Special Issue
  • - Volume 2014
  • - Article ID 239358
  • - Research Article

Elements of the B Cell Signalosome Are Differentially Affected by Mercury Intoxication

Randall F. Gill | Michael J. McCabe | Allen J. Rosenspire
  • Special Issue
  • - Volume 2014
  • - Article ID 782045
  • - Review Article

Autoimmunity and Asbestos Exposure

Jean C. Pfau | Kinta M. Serve | Curtis W. Noonan
  • Special Issue
  • - Volume 2014
  • - Article ID 325461
  • - Research Article

Mercury, Autoimmunity, and Environmental Factors on Cheyenne River Sioux Tribal Lands

Jennifer Ong | Esther Erdei | ... | Johnnye L. Lewis
  • Special Issue
  • - Volume 2014
  • - Article ID 260613
  • - Research Article

A Tandem Repeat in Decay Accelerating Factor 1 Is Associated with Severity of Murine Mercury-Induced Autoimmunity

David M. Cauvi | Rodney Gabriel | ... | K. Michael Pollard
  • Special Issue
  • - Volume 2014
  • - Article ID 743616
  • - Review Article

The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity

Datis Kharrazian
  • Special Issue
  • - Volume 2014
  • - Article ID 613157
  • - Research Article

Chronic Exposure to Oral Pathogens and Autoimmune Reactivity in Acute Coronary Atherothrombosis

Ivana Burazor | Aristo Vojdani
  • Special Issue
  • - Volume 2014
  • - Article ID 982073
  • - Research Article

Differential Immunotoxicity Induced by Two Different Windows of Developmental Trichloroethylene Exposure

Kathleen M. Gilbert | William Woodruff | Sarah J. Blossom
Autoimmune Diseases
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