Table of Contents
Advances in Environmental Chemistry
Volume 2015 (2015), Article ID 243785, 8 pages
http://dx.doi.org/10.1155/2015/243785
Research Article

Utilization of Cellulose from Luffa cylindrica Fiber as Binder in Acetaminophen Tablets

1Faculty of Science, Technology and Mathematics, College of Teacher Development, Philippine Normal University, 1000 Manila, Philippines
2College of Graduate Studies and Teacher Education Research, Philippine Normal University, 1000 Manila, Philippines

Received 27 September 2014; Revised 22 February 2015; Accepted 22 February 2015

Academic Editor: Jesus Simal-Gandara

Copyright © 2015 John Carlo O. Macuja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cellulose is an important pharmaceutical excipient. This study aimed to produce cellulose from the fiber of Luffa cylindrica as an effective binder in the formulation of acetaminophen tablets. This study was divided into three phases, namely, (I) preparation of cellulose from Luffa cylindrica, (II) determination of the powder properties of the LC-cellulose, and (III) production and evaluation of acetaminophen of the tablets produced using LC-cellulose as binder. The percentage yield of LC-cellulose was 61%. The values of the powder properties of LC-cellulose produced show fair and passable flow properties and are within the specifications of a powdered pharmaceutical excipient. The mean tablet hardness and disintegration time of the LC-cellulose tablets have a significant difference in the mean tablet hardness and disintegration time of the tablets without binder; thus the cellulose produced improved the suitability of acetaminophen in the dry compression process. However, the tablet properties of the tablets produced using LC-cellulose as binder do not conform to the specifications of the US pharmacopeia; thus the study of additional methods and excipients is recommended.