Table of Contents
Advances in Endocrinology
Volume 2017, Article ID 9256043, 11 pages
https://doi.org/10.1155/2017/9256043
Research Article

Evaluation of Prepubertal Patients with Suspected Neurosecretory Dysfunction of Growth Hormone Secretion: Diagnostic Steps and Treatment Response

Dr. v. Haunersches Children’s Hospital, Department of Pediatric Endocrinology, Ludwig Maximilians University of Munich, Munich, Germany

Correspondence should be addressed to Heinrich Schmidt; ed.nehcneumed.nehcneum-inu.dem@tdimhcs.hcirnieh

Received 10 October 2016; Revised 13 January 2017; Accepted 23 January 2017; Published 23 February 2017

Academic Editor: Massimiliano Ruscica

Copyright © 2017 Carmen Sydlik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. G. Rosenfeld, K. Albertsson-Wikland, F. Cassorla et al., “Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited,” Journal of Clinical Endocrinology and Metabolism, vol. 80, no. 5, pp. 1532–1540, 1995. View at Google Scholar · View at Scopus
  2. H. Schmidt, H. G. Dorr, O. Butenandt, A. Galli-Tsinopoulou, and W. Kiess, “Measurement of spontaneous, 12-hour sleep-associated GH secretion in prepubertal children with short stature: clinical relevance and practicability?” Hormone Research, vol. 46, no. 1, pp. 33–37, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. B. E. Spiliotis, G. P. August, W. Hung, W. Sonis, W. Mendelson, and B. B. Bercu, “Growth hormone neurosecretory dysfunction,” The Journal of the American Medical Association, vol. 251, no. 17, pp. 2223–2230, 1984. View at Publisher · View at Google Scholar · View at Scopus
  4. Z. Zadik, S. A. Chalew, Z. Gilula, and A. A. Kowarski, “Reproducibility of growth hormone testing procedures: a comparison between 24-hour integrated concentration and pharmacological stimulation,” Journal of Clinical Endocrinology and Metabolism, vol. 71, no. 5, pp. 1127–1130, 1990. View at Publisher · View at Google Scholar · View at Scopus
  5. Z. Zadik, S. A. Chalew, S. Raiti, and A. A. Kowarski, “Do short children secrete insufficient growth hormone?” Pediatrics, vol. 76, no. 3, pp. 355–360, 1985. View at Google Scholar · View at Scopus
  6. Z. Zadik, S. A. Chalew, and A. Kowarski, “The definition of a spontaneous growth hormone (GH) peak: studies in normally growing and GH-deficient children,” Journal of Clinical Endocrinology and Metabolism, vol. 74, no. 4, pp. 801–805, 1992. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Albertsson-Wikland and S. Rosberg, “Analyses of 24-hour growth hormone profiles in children: relation to growth,” Journal of Clinical Endocrinology and Metabolism, vol. 67, no. 3, pp. 493–500, 1988. View at Publisher · View at Google Scholar · View at Scopus
  8. J. R. Kerrigan, P. M. Martha, R. M. Blizzard, C. M. Christie, and A. D. Rogol, “Variations of pulsatile growth hormone release in healthy short prepubertal boys,” Pediatric Research, vol. 28, no. 1, pp. 11–12, 1990. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Coste, M. Letrait, J. C. Carel et al., “Long term results of growth hormone treatment in France in children of short stature: Population, Register Based Study,” British Medical Journal, vol. 315, no. 7110, pp. 708–713, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. G. L. Spadoni, S. Cianfarani, S. Bernardini et al., “Twelve-hour spontaneous nocturnal growth hormone secretion in growth retarded patients,” Clinical Pediatrics, vol. 27, no. 10, pp. 473–478, 1988. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Sydlik, C. Weißenbacher, J. Roeb, S. Bechtold-Dalla Pozza, and H. Schmidt, “Evaluation of prepubertal patients with suspected neurosecretory dysfunction for growth hormone secretion (NSD): diagnostic steps and treatment response,” http://abstracts.eurospe.org/hrp/0086/hrp0086P1-P633.htm.
  12. B. Bakker, J. Frane, H. Anhalt, B. Lippe, and R. G. Rosenfeld, “Height velocity targets from the national cooperative growth study for first-year growth hormone responses in short children,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 2, pp. 352–357, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Bang, S. F. Ahmed, J. Argente et al., “Identification and management of poor response to growth-promoting therapy in children with short stature,” Clinical Endocrinology, vol. 77, no. 2, pp. 169–181, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. M. B. Ranke and A. Lindberg, “Observed and predicted growth responses in prepubertal children with growth disorders: guidance of growth hormone treatment by empirical variables,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 3, pp. 1229–1237, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. B. Ranke, A. Lindberg, P. Chatelain et al., “Derivation and validation of a mathematical model for predicting the response to exogenous recombinant human growth hormone (GH) in prepubertal children with idiopathic GH deficiency,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 4, pp. 1174–1183, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. M. B. Ranke, A. Lindberg, D. A. Price et al., “Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature,” Hormone Research, vol. 68, no. 2, pp. 53–62, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. E. O. Reiter, D. A. Price, P. Wilton, K. Albertsson-Wikland, and M. B. Ranke, “Effect of Growth Hormone (GH) treatment on the near-final height of 1258 patients with idiopathic GH deficiency: analysis of a large international database,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 6, pp. 2047–2054, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. M. A. J. de Ridder, T. Stijnen, and A. C. S. Hokken-Koelega, “Prediction of adult height in growth-hormone-treated children with growth hormone deficiency,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 3, pp. 925–931, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Straetemans, M. Roelants, M. Thomas, R. Rooman, and J. de Schepper, “Reference curve for the first-year growth response to growth hormone treatment in prepubertal children with idiopathic growth hormone deficiency: validation of the KIGS first-year growth response curve using the belgian register for the study of growth and puberty problems,” Hormone Research in Paediatrics, vol. 81, no. 5, pp. 343–349, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Duché, C. Trivin, W. Chemaitilly et al., “Selecting short-statured children needing growth hormone testing: derivation and validation of a clinical decision rule,” BMC Pediatrics, vol. 8, pp. 29–36, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Koch and H.-G. Dörr, “Insulin-like growth factor-I and its binding protein-3 in serum: are they good screening properties for the diagnosis of growth hormone deficiency?” European Journal of Clinical Chemistry and Clinical Biochemistry, vol. 35, no. 5, pp. 379–385, 1997. View at Google Scholar · View at Scopus
  22. J.-P. Bourguignon, M. Vandeweghe, M. Vanderschueren-Lodeweyckx et al., “Pubertal growth and final height in hypopituitary boys: a minor role of bone age at onset of puberty,” The Journal of Clinical Endocrinology & Metabolism, vol. 63, no. 5, pp. 376–382, 1985. View at Google Scholar
  23. H. Jung, C. Land, W. F. Blum, and E. Schöenau, “Early differentiation between good and poor response to growth hormone therapy in short children born small for gestational age (SGA) to improve the outcome of poor responders,” Journal of Pediatric Endocrinology and Metabolism, vol. 27, no. 3-4, pp. 229–235, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. H.-P. Schwarz, D. Birkholz-Walerzak, M. Szalecki et al., “One-year data from a long-term phase IV study of recombinant human growth hormone in short children born small for gestational age,” Biologics in Therapy, vol. 4, no. 1, pp. 1–13, 2014. View at Publisher · View at Google Scholar
  25. I. Iomo, A. Mussa, S. Vanelli, F. Feyles, S. Einaudi, and P. Matarazzo, “Comparison of baseline parameters and response to GH treatment in 125 children with short stature with eight different diagnosis,” ESPE Abstracts, vol. 84, pp. 2–425, 2015. View at Google Scholar
  26. K. Albertsson-Wikland, A. S. Aronson, J. Gustafsson et al., “Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 11, pp. 4342–4350, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Coste, M. Letrait, J. C. Carel et al., “Long term results of growth hormone treatment in France in children of short stature: population, register based study,” British Medical Journal, vol. 315, no. 7110, pp. 708–713, 1997. View at Publisher · View at Google Scholar · View at Scopus