Research Article

Prediction of Ubiquitination Sites Using UbiNets

Table 1

Related work in chronological order.

S. number YearTitle Technique and results

(1)2008Computational identification of ubiquitylation sites from protein sequences [11]Authors used svm, knn, and naive Bayes for analysis and obtained 84.44% accuracy

(2)2010Identification, analysis, and prediction of protein ubiquitination sites [12]Authors used random forest predictor as classification model and obtained 72% accuracy

(3)2011Prediction of ubiquitination sites by using the composition of -spaced amino acid pairs [13]Authors used SVM as classification model and obtained accuracy of 73.40%

(4)2013hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties [14]Authors used SVM as classification model based on the composition of -spaced amino acid pairs and obtained accuracy of 75.7%

(5)2014RUBI: rapid proteomic-scale prediction of lysine ubiquitination and factors influencing predictor performance [15]Authors proposed Rapid UBIquitination (RUBI), a sequence-based ubiquitination predictor, and obtained 86.8% accuracy

(6)2014Transient protein-protein interface prediction: datasets, features, algorithms, and the RAD-T predictor [16]Authors proposed RA-T prediction model and obtained 44% improvement across multiple machine learning algorithm

(7)2016Prediction of ubiquitination sites with feature weighting scheme and naive Bayes vectorizer [17]Category based feature weighting scheme is used and prediction model. Proposed technique performed better than SVM

(8)2016ESA-UbiSite: accurate prediction of human ubiquitination sites by identifying a set of effective negatives [18]Authors used evolutionary screening algorithm and obtained testing accuracy 92% and Matthews’ correlation 0.48

(9)2016Noncanonical pathway network modelling and ubiquitination site prediction through homology modelling of NF-κB [19]Authors used loop_model and asses_dope functions and enhanced understanding of cofactors involved and ubiquitination sites employed during the activation process

(10)2016Computational methods for ubiquitination site prediction using physicochemical properties of protein sequences [20]Authors used various techniques like SVM and naive Bayes for predictionm and obtained AUC value greater than or equal to 0.6

(11)2017A new scheme to characterize and identify protein ubiquitination sites [21]Authors used SVM as prediction model and obtained 68.70% average accuracy