this studi investig method predict medic outcom cholinesteras inhibitor patient alzheimer diseas vascular dementia vad van gool predict patient cholinerg deficit symptom benefit from treatment wherea patient without experi side effect becaus overstimul cholinerg system predict vad patient longer experi fewer side effect than patient faster respons vad patient have longer than patient number 71 patient vad diagnosi were includ sustain attent task administ well mmse questionnair about side effect result indic vad patient longer report fewer side effect furthermor patient vad had longer than patient mmse negat correl vad group thus perform attent task seem associ suffer from side effect thus tend predict medic outcom vad perhap attent task sensit enough measur cholinerg deficit symptom patient furthermor differ dose medic might confound effect group

Liza van Eijk

Erwin R. Groot

Maritza van Spronsen

Yvonne J. Maas

Daniel Keeser

Oliver Pogarell

Hessel J. Engelbregt

Testing Van Gool&#x2019;s Hypothesis: A Method to Predict Side Effects of Cholinesterase Inhibitors in Patients with Cellular Degenerative and Vascular Dementia

frailti wellrecognis complex syndrom predomin affect older peopl current two main conceptu frailti phenotyp accumul deficit model phenotyp model be more wide appli clinic research base model contend number phenotyp frailti compon weak slow low energi expenditur potenti revers this paper outlin result frailti research program summar initi frailti treatment model report it effect briefli effect twelvemonth individu tailor multifactori interdisciplinari intervent target frailti compar usual care the intervent reduc phenotyp defin frailti improv mobil further contend evid substanti unmet need due treatment fragment absenc comprehens approach popul our paper outlin current stage our research which model now be extend prefrailti intervent aim revers frailti syndrom it consequ onli earli stage there signific scope futur research identifi optim manag program frail older peopl

Ian D. Cameron

Nicola Fairhall

Liz Gill

Keri Lockwood

Colleen Langron

Christina Aggar

Noeline Monaghan

Susan Kurrle

Developing Interventions for Frailty

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Advances in Geriatrics

Advances in Geriatrics

Table of Contents

Table of Contents: 2015

Testing Van Gool’s Hypothesis: A Method to Predict Side Effects of Cholinesterase Inhibitors in Patients with Cellular Degenerative and Vascular Dementia

Developing Interventions for Frailty