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Advances in Hematology
Volume 2009 (2009), Article ID 153643, 5 pages
http://dx.doi.org/10.1155/2009/153643
Case Report

Low-Molecular-Weight Heparin Use in a Case of Noncardiogenic Multifocal Perinatal Thromboembolic Stroke

1Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL 32610-0296, USA
2Division of General Pediatrics, Department of Pediatrics, University of Florida, Gainesville, FL 32610-0296, USA
3Division of Neurology, Department of Pediatrics, University of Florida, Gainesville, FL 32610-0296, USA
4Department of Radiology, University of Florida, Gainesville, FL 32610-0296, USA
5Division of Hematology/Oncology, Department of Pediatrics, University of Florida, Gainesville, FL 32610-0296, USA
6Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation and Center for Cancer and Blood Disorders, The Children's Hospital, University of Colorado, Denver School of Medicine, Aurora, CO 80045, USA
7Division of Neurology and Sleep Medicine, Department of Internal Medicine, College of Community Health Sciences, University of Alabama, Tuscaloosa, AL 35487, USA

Received 22 October 2008; Accepted 13 January 2009

Academic Editor: Charles S. Greenberg

Copyright © 2009 Matthew A. Saxonhouse et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A full-term neonate suffered multifocal cerebral infarctions due to multiple large vessel thrombi. Thrombophilia and cardiovascular assessments were negative, but due to the severity of the lesions and the concern for expansion of the thrombi or future embolic events, treatment with low-molecular-weight heparin (LMWH) was initiated. No complications from treatment were experienced. We present this severe case in order to highlight difficult management decisions for newborns with multifocal perinatal thromboembolic stroke and to stress the need for further practice guidelines and research in this area.