Table of Contents Author Guidelines Submit a Manuscript
Advances in Hematology
Volume 2009, Article ID 689639, 5 pages
http://dx.doi.org/10.1155/2009/689639
Clinical Study

Vitamin E and N-Acetylcysteine as Antioxidant Adjuvant Therapy in Children with Acute Lymphoblastic Leukemia

1Hematology/Oncology Unit, Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, 35516 Mansoura, Egypt
2Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, 35516 Mansoura, Egypt
3Clinical Pathology Department, Faculty of Medicine, Mansoura University, 35516 Mansoura, Egypt

Received 3 December 2008; Revised 27 June 2009; Accepted 15 September 2009

Academic Editor: Sagar Lonial

Copyright © 2009 Youssef Al-Tonbary et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. H. Chelf, P. Agre, A. Axelrod et al., “Cancer-related patient education: an overview of the last decade of evaluation and research,” Oncology Nursing Forum, vol. 28, no. 7, pp. 1139–1147, 2001. View at Google Scholar · View at Scopus
  2. D. W. Lamson and M. S. Brignall, “Antioxidants in cancer therapy; their actions and interactions with oncologic therapies,” Alternative Medicine Review, vol. 4, no. 5, pp. 304–329, 1999. View at Google Scholar · View at Scopus
  3. R. W. Moss, “Should patients undergoing chemotherapy and radiotherapy be prescribed antioxidants?” Integrative Cancer Therapies, vol. 5, no. 1, pp. 63–82, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. A. Bendich and L. J. Machlin, “Safety of oral intake of vitamin E,” American Journal of Clinical Nutrition, vol. 48, no. 3, pp. 612–619, 1988. View at Google Scholar · View at Scopus
  5. C. A. Gogos, P. Ginopoulos, B. Salsa, E. Apostolidou, N. C. Zoumbos, and F. Kalfarentzos, “Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial,” Cancer, vol. 82, no. 2, pp. 395–402, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Arora-Kuruganti, P. A. Lucchesi, and R. D. Wurster, “Proliferation of cultured human astrocytoma cells in response to an oxidant and antioxidant,” Journal of Neuro-Oncology, vol. 44, no. 3, pp. 213–221, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. J. W. Chiao, F. Chung, J. Krzeminski et al., “Modulation of growth of human prostate cancer cells by the N-acetylcysteine conjugate of phenethyl isothiocyanate,” International Journal of Oncology, vol. 16, no. 6, pp. 1215–1219, 2000. View at Google Scholar · View at Scopus
  8. G. Henze, H. J. Langermann, and J. Braemswig, “Ergebnisse der studie BFM 76/79 zur behandlung der akuten lymphoblastischen leukamie bei kindern und jugendlichen,” Klinische Padiatrie, vol. 193, no. 3, pp. 145–154, 1981. View at Google Scholar · View at Scopus
  9. M. A. Richardson, T. Sanders, J. L. Palmer, A. Greisinger, and S. E. Singletary, “Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology,” Journal of Clinical Oncology, vol. 18, no. 13, pp. 2505–2514, 2000. View at Google Scholar · View at Scopus
  10. M. Hadir, B. Ibrahim, N. Hala, E. Hanaa, and E. Alaa, “Hepatic dysfunction in children with acute lymphoblastic leukemia in remission: relation to hepatitis infection,” Medical and Pediatric Oncology, vol. 36, no. 4, pp. 469–473, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. D. E. Paglia and W. N. Valentine, “Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase,” The Journal of Laboratory and Clinical Medicine, vol. 70, no. 1, pp. 158–169, 1967. View at Google Scholar · View at Scopus
  12. H. H. Draper, E. J. Squires, H. Mahmoodi, J. Wu, S. Agarwal, and M. Hadley, “A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials,” Free Radical Biology and Medicine, vol. 15, no. 4, pp. 353–363, 1993. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Beutler and A. Cerami, “Cachectin: more than a tumor necrosis factor,” The New England Journal of Medicine, vol. 316, no. 7, pp. 379–385, 1987. View at Google Scholar · View at Scopus
  14. E. J. Ladas, J. S. Jacobson, D. D. Kennedy, K. Teel, A. Fleischauer, and K. M. Kelly, “Antioxidants and cancer therapy: a systematic review,” Journal of Clinical Oncology, vol. 22, no. 3, pp. 517–528, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. D. D. Kennedy, E. J. Ladas, S. R. Rheingold, J. Blumberg, and K. M. Kelly, “Antioxidant status decreases in children with acute lymphoblastic leukemia during the first six months of chemotherapy treatment,” Pediatric Blood and Cancer, vol. 44, no. 4, pp. 378–385, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. O. Portakal, O. Ozkaya, M. Erden Inal, B. Bozan, M. Koşan, and I. Sayek, “Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients,” Clinical Biochemistry, vol. 33, no. 4, pp. 279–284, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Ray, S. Batra, N. K. Shukla et al., “Lipid peroxidation, free radical production and antioxidant status in breast cancer,” Breast Cancer Research and Treatment, vol. 59, no. 2, pp. 163–170, 2000. View at Google Scholar
  18. G. Mantovani, A. Macciò, C. Madeddu et al., “Quantitative evaluation of oxidative stress, chronic inflammatory indices and leptin in cancer patients: correlation with stage and performance status,” International Journal of Cancer, vol. 98, no. 1, pp. 84–91, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. G. Mantovani, A. Macciò, C. Madeddu et al., “The impact of different antioxidant agents alone or in combination on reactive oxygen species, antioxidant enyzmes and cytokines in a series of advanced cancer patients at different sites: correlation with disease progression,” Free Radical Research, vol. 37, no. 2, pp. 213–223, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Mantovani, C. Madeddu, A. Macciò et al., “Cancer-related anorexia/cachexia syndrome and oxidative stress: an innovative approach beyond current treatment,” Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 10, pp. 1651–1659, 2004. View at Google Scholar · View at Scopus
  21. G. Mantovani, A. Macciò, L. Mura et al., “Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites,” Journal of Molecular Medicine, vol. 78, no. 10, pp. 554–561, 2000. View at Publisher · View at Google Scholar · View at Scopus