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Advances in Hematology
Volume 2009, Article ID 963506, 12 pages
Research Article

Comorbidities of Idiopathic Thrombocytopenic Purpura: A Population-Based Study

1Worldwide Epidemiology, GlaxoSmithKline R & D, Greenford, Middlesex, UB6 0HE, UK
2Institut National de la Statistique et de l’Analyse Economique (INSAE), Campus de Ker Lann, rue Blaise Pascal, BP 37203, Bruz Cedex 35172, France
3Worldwide Epidemiology, GlaxoSmithKline R & D, Five Moore Drive, Research Triangle Park, NC 27709, USA
4Worldwide Epidemiology, GlaxoSmithKline R & D, Greenford, Middlesex UB6 0HE, UK
5Pharma Development Safety, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland

Received 10 October 2008; Accepted 1 December 2008

Academic Editor: Simon Karpatkin

Copyright © 2009 M. A. Feudjo-Tepie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A person experiencing more than one medical condition may have ambiguous clinical presentation. ITP is a serious autoimmune disease with little epidemiological evidence on its burden, risk factors, and comorbidities. Using the United Kingdom general practice research database, we conducted a 14 years population-based case control-type study to explore medical conditions more likely to cooccur with ITP and their temporal relationship in association with ITP. ITP patients were matched to non-ITP on practice, age, gender, and follow-up period. Potential comorbidities were represented by patients’ medical information at the preferred term level of the MedDRA international classification. As well as death ( O R = 6 0 . 0 ; 95% CI [4.47–806.0]) and known clinical signs and symptoms of ITP, ITP is associated with considerable number of medical conditions. The association between ITP and some of these conditions is apparent both before and after ITP diagnosis. Specific targeted studies can now be setup to reexamine observed associations.