Table 1: Clinical features of patients with MS in APL.

ReferencesNo. casesdisease statusTime sinceSite of involvement
diagnosis/EMD relapse (months)

Fukushima et al. [31]1onsetcerebellum + hematological
Worch et al. [32]1onsetlytic lesions of humerus, tibia, femur + molecular hematological
Ajarim et al. [33]1onsetthymus + hematological
Savranlar et al. [34]1onsetthoracic-epidural
Brown et al. [35]1onsetoptic nerve + hematological
Agarwal et al. [36]1relapse31hip + hematological
Disel et al. [37]1relapse9pleura
Tsimberodou et al. [30]1relapse36thoracic spine
Specchia et al. [38]1relapseNAlung + hematological
3relapse155mastoid + hematological
Latagliata et al. [39]71mastoid + mol hematological
61mastoid
3relapse7subcutaneous nodules at sternal manubrium + wrist at level of the radial artery pulse + site of intravenous catheter scar+ mol hematological
Sanz et al. [40]6 subcutaneous nodules at jugular catheter scar + wrists at level of the radial artery pulse + molecular hematological
32sternal manubrium + subcutaneous nodule + antecubital fossa
Magliulo et al. [41]1relapse24external auditory canal+ mol hematological
Nasilowska-Adamska et al. [42]1relapse21pleura, heart and pericardium
Slavecheva et al. [43]1relapse120lymph node
Kai et al. [44]1relapsesNA4 time at different sites
Tobita et al. [45]1relapsesNA1st and 2nd external auditory canal
Forrest et al. [46]1relapse1st 48-2nd 241st testicular -2nd retroperitoneal nodes, psoas muscle and skin
Skarin et al. [47]1relapse8CNS + hematologic
Leoni et al. [48]2relapseNA(1) central nervous system + middle ear + lymph nodes.
(2) skin + lymph nodes
Ammatuna et al. [49] 1relapse NA1st and 2nd -scalp + mol hematological 3rd mol hematological + breast
Breccia et al. [50]7relapse5 from CR(1) left auricular canal + mastoid + mol hematological
69(2) left mastoid + mol hematological
58(3) left mastoid
9(4) left mastoid + hematologic
12(5) left mastoid + hematologic
64(6) right auricular canal
6 from 2nd CR(7) right mastoid + CNS + mol hematological

NA: not available; mol: molecular; CR: complete remission;