Iron Overload in Patients Undergoing Hematopoietic Stem Cell Transplantation

Table 3

Published guidelines for managing iron overload in HSCT recipients.

Source of guidelines	Focus of guidelines	Recommendations for management of iron load
Nagasaki consensus group (2005) [58]	Consensus statement on iron overload in MDS	(i)  Candidates for allograft could benefit from management of iron load with chelation therapy
European Group for Blood and Marrow transplantation, the Center for International Blood and Marrow Transplant Research and the American Society for Blood and Marrow transplantation (2006) [59]	Long-term survivors of HSCT	(i)  Most long-term survivors will have some  degree  of  iron overload (ii)  LIC  >7 mg Fe/g dry weight (dw) should be treated with phlebotomy and/or chelation therapy
MDS Foundation’s Working Group on Transfusional Iron Overload (2008) [60]	Consensus statement on iron overload in MDS patients	(i)  Allograft candidates may benefit from chelation therapy in order to manage body iron levels prior to transplantation in order to avoid iron-related organ dysfunction and transplant-related morbidity and mortality
Canadian consensus group (2008) [61]	Iron overload in MDS	(i)  Consider iron chelation in transfusion-dependent patients who are candidates for allogeneic HSCT