Membrane topology of FPN1. Topology of FPN1 protein is schematically represented, modified from two alternative models proposed by Devalia et al. (on the top) [16] and Liu et al. (on the bottom) [13]: the 9 or 12 predicted transmembrane helices (vertical green rectangles) are shown in relation to the lipid bilayer (horizontal violet rectangle). The positions of the mutations are marked as orange circles. The N- and C-termini are denoted by N and C, respectively. The length of extra-membranous segments is indicated.
