Case Report
Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients
Table 2
Clinical course of Adenovirus infections.
| | Clinical Presentation | Diagnosis of Adenovirus | Therapy for Adenovirus | Viral Outcome (copies/ml) | Current Status |
| | 1 | Hepatitis
Day +98 | Autopsy | None | Death | Death
Day +101 | | 2 | Pulmonary
Day +180 | Serum* and BAL PCR | Cidofovir 1mg/kg
QOD 7 doses
IVIG 1 dose | 45,000→ 2,000→ negative | ECOG 4
Day +392 | | 3 | Pulmonary
Day +64 | Serum* PCR | Cidofovir 4mg/kg
qweek 3 doses | 560,000→ 25,700→ death prior to repeat | Death
Day +92 | | 4 | Cystitis
Day +168 | Serum, CSF, Urine* PCR | Cidofovir 1mg/kg
QOD 3 doses
IVIG 2 doses | 2 mill→ 15 mill → 800→ no repeat | ECOG 1
Day +434 | | 5 | Cystitis
Day +218 | Urine*, and Serum PCR | Cidofovir 1mg/kg
QOD 7 doses | 370,000→ 1,000→ no repeat | Death
Day +1020 | | 6 | Pulmonary
Day +30 | Serum*, BAL, and Stool PCR | Cidofovir 1mg/kg
QOD 5 doses
IVIG 3 | 18,000→ death prior to repeat | Death
Day +46 |
|
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*used to determine viral outcome.
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