Hodgkin's Lymphomas: A Tumor Recognized by Its Microenvironment

Figure 1

NLP-HL: HE section of a case of Nodular lymphocyte-predominant Hodgkin lymphoma, showing a typical lymphocyte-Predominant (LP) cell positive for CD20 (NLP-CD20) and surrounded by a rim of PD1-positive T cells (NLP-PD1). LR-CHL: HE section of a case of lymphocyte-Rich Classical Hodgkin lymphoma that highlights a typical Reed-Sternberg (R-S) cell with the characteristic phenotype (CD30+, LR-CD30) and surrounded by a rim of PD1-positive T cells (LR-PD1). The pattern is reminiscent of that found in the outer part of the germinal centre where PD1-positive cells surround large B blasts (see arrows in the immunofluorescence capture region of the outer zone of a reactive germinal centre).