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Advances in Hematology
Volume 2011, Article ID 398945, 10 pages
Research Article

Predicting the Kinetic Properties Associated with Redox Imbalance after Oxidative Crisis in G6PD-Deficient Erythrocytes: A Simulation Study

1Institute for Advanced Biosciences, Keio University, 403-1, Daihoji, Tsuruoka, Yamagata 997-0017, Japan
2Department of Environment and Information Studies, Keio University, Endo 5322, Fujisawa, Kanagawa 252-8520, Japan
3Systems Biology Program, Graduate School of Media and Governance, Keio University, Endo 5322, Fujisawa, Kanagawa 252-8520, Japan

Received 30 April 2011; Revised 15 June 2011; Accepted 15 June 2011

Academic Editor: Ufuk Çakatay

Copyright © 2011 Hanae Shimo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary material contains additional simulation results that were used to construct Figures 3, 4, and 6, and make an assumption of the relationship between the indicators of redox imbalance. It also includes a detailed description of the E-Cell human erythrocyte model, involving the initial steady state concentrations of substrates and the kinetic equations and parameters used for simulation.

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