Clinical Study

Steroid-Refractory Acute GVHD: Predictors and Outcomes

Table 6

The Effect of severity, hyperacute GVHD, and response to corticosteroids on nonrelapse morality.

HyperacuteNRM at 100 daysNRM at 1 year
GroupGradeGVHDCR or PR % CIHR % CIHR

11 or 2NoYes1109%Reference27%Reference
21 or 2NoNo6023%2.80.0155%2.5<0.001
31 or 2YesYes293%0.40.334%1.10.7
41 or 2YesNo3131%4.9<0.00145%2.50.003
53 or 4NoYes2025%2.90.0535%1.40.4
63 or 4NoNo2450%7.6<0.00175%4.7<0.001
73 or 4YesYes2100%Excluded100%Excluded
83 or 4YesNo1170%11.6<0.00180%6.2<0.001

% CI: percent cumulative incidence; NRM: nonrelapse mortality; —: nonapplicable, KM: Kaplan-Meier.