Review Article

Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia

Table 2

Cytogenetic molecular classification of adult ALL based on more recently published data.

Risk groupChromosomal/molecular aberrations5y-DFS5y-OS

STANDARD-RISKIsolated 9p/p15-p16 deletions
High hyperdiploidy
Normal karyotype/no molecular aberrations
35–68%48–80%

INTERMEDIATE-RISKdel(6q)
Trisomy of chromosome 21
Trisomy of chromosome 8
t(1;19)/E2A-PBX
37–51%35–40%

HIGH-RISKt(9;22)/BCR-ABL
t(4;11)/MLL-AF4
11q23 MLL rearrangements
Monosomy of chromosome 7
Low hypodiploidy/near triploidy
Complex karyotype
High BAALC expression
Aberrations of IKZF1 gene
10–52%15–35%

CR: complete remission; 5y-DFS: 5 years disease-free survival; 5y-OS: 5 years overall survival.