Towards Curative Therapy in Burkitt Lymphoma: The Role of Early African Studies in Demonstrating the Value of Combination Therapy and CNS Prophylaxis

Table 1

Drug	No. of patients	CR	CR + PR	%OR
Cyclophosphamide	163	43	132	81
Orthomerphalan	14	UK	14	100
Chlorambucil	12	3	10	83
Nitrogen mustard	61	10	44	72
Melphalan	26	8	16	61
Procarbazine	6	0	0	0
BCNU	5	0	4	80
Vincristine	21	10	17	81
Vinblastine	2	0	0	0
Methotrexate	45	11	26	58
6-Mercaptopurine	3	0	0	0
Cytosine arabinoside	3	2	2	2
Epipodophyllotoxin	2	2	2	2
Actinomycin D	4	1	4	4

CR: complete response; PR: partial respo2nse; OR: overall response.
Various doses and schedules were used, even for the same drug.
Adapted slightly from [12], UK = unknown.