AIDS-Related Non-Hodgkin's Lymphoma in the Era of Highly Active Antiretroviral Therapy

Table 2

Active clinical trial protocols evaluating chemotherapy in ARL.

Study identifier	Phase	Study regimen	Start date	Primary endpoint
NCT00006436	II	EPOCH and Rituximab in ARL	October 2000	PFS
NCT00598169 (AMC 053)	I/II	Bortezomib, Ifosfamide, Carboplatin, and Etoposide ± Rituximab in relapsed ARL	November 2007	ORR and safety
NCT01092182	II	Dose-adjusted R-EPOCH in Burkitt or c-MYC+ DLBCL	February 2010	PFS, EFS, and OS
NCT01193842 (AMC 075)	I/II	R-CHOP or R-EPOCH ± Vorinostat in AIDS-related DLBCL	October 2010	ORR, MTD, and toxicity

EPOCH: etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin; ARL: AIDS-related lymphoma; PFS: progression-free survival; AMC: AIDS Malignancy Consortium; ASCT: autologous stem cell transplant; PET: positron emitting tomography; CT: computed tomography; ABVD: doxorubicin, bleomycin, vinblastine, dacarbazine; BEACOPP: bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone; HL: Hodgkin’s lymphoma; OS: overall survival; ORR: overall response rate; DLBCL: diffuse large B cell lymphoma; EFS: event-free survival; R-CHOP: rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone; MTD: maximum tolerated dose.
Source: http://clinicaltrials.gov/.