TY - JOUR A2 - Tomasson, Michael H. AU - Tzifi, Flora AU - Economopoulou, Christina AU - Gourgiotis, Dimitrios AU - Ardavanis, Alexandros AU - Papageorgiou, Sotirios AU - Scorilas, Andreas PY - 2012 DA - 2011/09/14 TI - The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias SP - 524308 VL - 2012 AB - The disturbance of apoptosis molecular signaling pathways is involved in carcinogenesis. BCL2 family of proteins is the hallmark of apoptosis regulation. In the last decade, new members of BCL2 gene family were discovered and cloned and were found to be differentially expressed in many types of cancer. BCL2 protein family, through its role in regulation of apoptotic pathways, is possibly related to cancer pathophysiology and resistance to conventional chemotherapy. It is well known that leukemias are haematopoietic malignancies characterized by biological diversity, varied cytogenetics, different immunophenotype profiles, and diverse outcome. Current research focuses on the prognostic impact and specific role of these proteins in the pathogenesis of leukemias. The understanding of the molecular pathways that participate in the biology of leukemias may lead to the design of new therapies which may improve patients' survival. In the present paper, we describe current knowledge on the role of BCL2 apoptosis regulator proteins in acute and chronic leukemias. SN - 1687-9104 UR - https://doi.org/10.1155/2012/524308 DO - 10.1155/2012/524308 JF - Advances in Hematology PB - Hindawi Publishing Corporation KW - ER -