Review Article
The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias
Table 1
This table summarizes the general findings regarding BCL2 family members in each type of leukemia.
| Type of Leukemia | BCL2 family members involved in disease | Correlation with overall survival and outcome |
| ALL | High levels: BCL2, BAX, MCL-1 | No correlation | ↑MCL-1 → resistance to chemotherapy |
| AML | High levels: BCL2, BCL-XL, BAD, BCL2/BAX ratio especially in M4,M5,M6 subtypes and in CD34+ blasts | ↑BCL2 and FAS → no correlation | ↑BAD and BAX, ↑BCL2/BAX ratio → worse outcome |
| CLL | High levels: BCL2, BCL-W, BAD, BAK, BAX, BCL2/BAX ratio | Conflicting results | No participation of BIK and BCL-XL | ↑MCL-1, ↑BAX, ↑BAG-1 ↑BCL2 → resistance to chemotherapy |
| CML | High levels: MCL-1, BCL2 Low levels of BIM | BCL2: key protein in disease progression |
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