Review Article

Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma: An Underrecognized Aggressive Lymphoma

Table 1

Differential diagnosis of ALK+ LBCL and predominant staining patterns with several antibodies. This table summarizes the predominant staining patterns for these entities, with the understanding that exceptional cases have been reported. Typically, ALK+ LBCL demonstrates a postgerminal center phenotype and is negative for CD30. Rare cases expressing CD20, CD79a, or CD30 have been reported [5].

ALK+ LBCLALK+ ALCLDLBCL, NOSPoorly differentiated carcinomaExtramedullary plasmacytoma

CD45+++
CD20+
CD79a++
MUM-1++/−
CD138++/−+
ALK++
CD30++/−
EMA+++/−
Keratin+/−+/−
EBER